2. Gene
  3. Ercc3 - excision repair cross-complementing rodent repair deficiency, complementation group 3 Gene

Ercc3 - excision repair cross-complementing rodent repair deficiency, complementation group 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as XPB; Ercc-3; BTF2 p89

Gene ID: 13872 | Gene type: protein coding

About Ercc3

Summary

Enables ATP hydrolysis activity and promoter-specific chromatin binding activity. Acts upstream of or within UV protection and transcription elongation from RNA polymerase I promoter. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex; nucleotide-excision repair factor 3 complex; and transcription preinitiation complex. Is expressed in several structures, including brain; eye; liver; oral region epithelium; and tooth. Used to study xeroderma pigmentosum group B. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; photosensitive trichothiodystrophy 2; trichothiodystrophy; xeroderma pigmentosum; and xeroderma pigmentosum group B. Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Apr 2022]

Ercc3 Products(1)

mRNA Protein Name
NM_133658.2 NP_598419.1 general transcription and DNA repair factor IIH helicase subunit XPB
Protein Preferred Names Protein Names

general transcription and DNA repair factor IIH helicase subunit XPB

DNA excision repair protein ERCC-3

DNA repair protein complementing XP-B cells

TFIIH 89 kDa subunit

TFIIH basal transcription factor complex helicase XPB subunit

basic transcription factor 2 89 kDa subunit

xeroderma pigmentosum group B-complementing

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-141549 BPK-21 99.56% Unkown
HY-D2331 ZL-12A probe 99.71% Unkown
HY-RS04480 ERCC3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS19680 Ercc3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26173 Ercc3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ercc3 NCBI NCBI:2071