PTPDC1 - protein tyrosine phosphatase domain containing 1 Gene

Homo sapiens

Also known as PTP9Q22

Gene ID: 138639 | Gene type: protein coding

About PTPDC1

This gene has 5 transcripts (splice variants), 201 orthologues and 8 paralogues. Broad expression in testis (RPKM 3.6), adrenal (RPKM 2.2) and 24 other tissues.

Summary

The protein encoded by this gene contains a characteristic motif of Protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

PTPDC1 Products(4)

mRNA	Protein	Name
NM_001253829.2	NP_001240758.1	protein tyrosine phosphatase domain-containing protein 1 isoform 3
NM_001253830.2	NP_001240759.1	protein tyrosine phosphatase domain-containing protein 1 isoform 4
NM_152422.4	NP_689635.3	protein tyrosine phosphatase domain-containing protein 1 isoform 1
NM_177995.3	NP_818931.1	protein tyrosine phosphatase domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPDC1 Protein Structure

DSPc

0
200
400
600
754 a.a.

Protein Preferred Names

Protein Names

protein tyrosine phosphatase domain-containing protein 1

protein tyrosine phosphatase PTP9Q22

PTPDC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPDC1	A2A3K4	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	PTPDC1	A2A3K4	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	PTPDC1	A2A3K4	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	PTPDC1	A2A3K4	TEX11	Homo sapiens	Q8IYF3-3	Y2H Prey Pooling	32296183
Intra	PTPDC1	A2A3K4	TEX11	Homo sapiens	Q8IYF3-3	Validated Y2H	32296183
Intra	PTPDC1	A2A3K4	TEX11	Homo sapiens	Q8IYF3-3	Y2H Array	32296183
Intra	PTPDC1	A2A3K4	CRKL	Homo sapiens	P46109	Y2H Array	32296183
Intra	PTPDC1	A2A3K4	CRKL	Homo sapiens	P46109	Y2H Prey Pooling	32296183
Intra	PTPDC1	A2A3K4	CRKL	Homo sapiens	P46109	Validated Y2H	32296183
Intra	PTPDC1	A2A3K4	MAPK1	Homo sapiens	P28482	Y2H Prey Pooling	32296183
Intra	PTPDC1	A2A3K4	MAPK1	Homo sapiens	P28482	Validated Y2H	32296183
Intra	PTPDC1	A2A3K4	MAPK1	Homo sapiens	P28482	Y2H Array	32296183
Intra	PTPDC1	A2A3K4	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11413	PTPDC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21917	Ptpdc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTPDC1	MGD	MGI:2145430
Canis familiaris	PTPDC1	VGNC	VGNC:45165
Bos taurus	PTPDC1	VGNC	VGNC:33527
Felis catus	PTPDC1	VGNC	VGNC:64430
Rattus norvegicus	PTPDC1	RGD	RGD:1307698
Macaca mulatta	PTPDC1	VGNC	VGNC:76567

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