2. Gene
  3. En1 - engrailed 1 Gene

En1 - engrailed 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as En-1; Mo-en.1; engrailed-1

Gene ID: 13798 | Gene type: protein coding

About En1

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; drinking behavior; and motor learning. Acts upstream of or within several processes, including embryonic forelimb morphogenesis; nervous system development; and regionalization. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb; and limb primordium. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

En1 Products(1)

mRNA Protein Name
NM_010133.3 NP_034263.2 homeobox protein engrailed-1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
23863478 MGI
Biological Process GO Annotation Evidence Reference Source
involved in adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
17267560 MGI
involved in cerebellum development IGI
IGI: Inferred from genetic interaction
8848044 MGI
acts upstream of or within dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
15175251 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
8684466 MGI
involved in drinking behavior IMP
IMP: Inferred from mutant phenotype
17267560 MGI
involved in embryonic brain development IMP
IMP: Inferred from mutant phenotype
7624797 MGI
acts upstream of or within embryonic forelimb morphogenesis IGI
IGI: Inferred from genetic interaction
9362463 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
15242796 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
8684466 MGI
involved in embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
7624797 MGI
acts upstream of or within hindbrain development IGI
IGI: Inferred from genetic interaction
15607945 MGI
acts upstream of or within limb development IMP
IMP: Inferred from mutant phenotype
23863478 MGI
acts upstream of or within midbrain development IGI
IGI: Inferred from genetic interaction
15175251 MGI
involved in midbrain development IGI
IGI: Inferred from genetic interaction
8848044 MGI
acts upstream of or within midbrain-hindbrain boundary development IMP
IMP: Inferred from mutant phenotype
15607945 MGI
involved in motor learning IMP
IMP: Inferred from mutant phenotype
17267560 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
23863478 MGI
involved in negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
15175251 MGI
acts upstream of or within neuron development IGI
IGI: Inferred from genetic interaction
11312297 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
23863478 MGI
acts upstream of or within neuron differentiation IGI
IGI: Inferred from genetic interaction
15340832 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
9362463 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9102311 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: Inferred from mutant phenotype
8684466 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
23863478 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23863478 MGI
involved in social behavior IMP
IMP: Inferred from mutant phenotype
17267560 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein engrailed-1

homeobox protein en-1

mo-En-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (41)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-139298 L319 ≥98.0% Unkown
HY-W010639 4-Penten-1-ol 99.78% Unkown
HY-W015515 L-Citronellol 99.92% Unkown
HY-46575 (R)-2-(But-3-en-1-yl)oxirane Control 99.79% Unkown
HY-W000981 1-Cyclopentenylboronic acid ≥97.0% Unkown
HY-34409 3-Methyl-2-butenal 97.30% Unkown
HY-W016976 Allyl heptanoate ≥95.0% Unkown
HY-139456S 1-(4-Aza-8-hydroxy-6-oxo)oct-2-en-1-oylimidazole-d3 / Unkown
HY-CE00800A 3-(4-Methylpent-3-en-1-yl)pent-2-enedioyl-CoA / Unkown
HY-CE00868 3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA / Unkown
HY-N12135 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide / Unkown
HY-N1873 (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol / Unkown
HY-N2296 (2R,3R)-3,7-Dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)chroman-4-one / Unkown
HY-RS04365 EN1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W015936 (E)-Hex-2-en-1-ol 99.96% Unkown
HY-W017558 (Z)-Non-6-en-1-ol / Unkown
HY-W127449 trans-2-Nonen-1-ol / Unkown
HY-W283271 3-Methylcyclohex-2-en-1-ol / Unkown
HY-Y0400S 2-Bromoethylammonium-d4 bromide / Unkown
HY-Z2289S1 (S)-Ibrutinib-d4 / Unkown
HY-165707 3-(((Z)-Octadec-9-en-1-yl)oxy)propane-1,2-diyl dioleate / Unkown
HY-165708 7(E)-Nonadecenol / Unkown
HY-165708A (Z)-Nonadec-7-en-1-ol / Unkown
HY-165728 (Z)-Octadec-9-en-1-yl methylglycinate / Unkown
HY-165841 11(E)-Octadecenol / Unkown
HY-165883 15(Z)-Tetracosenol / Unkown
HY-165894 Myristoleyl behenate / Unkown
HY-166005 Myristoleyl laurate / Unkown
HY-166006 Myristoleyl myristate / Unkown
HY-N12898 (Z)-Tetradec-7-en-1-ol Activator / Unkown
HY-N9018 4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one / Unkown
HY-RS17866 En1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24335 En1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W008836S (E)-Hex-3-en-1-ol-d2 / Unkown
HY-W026038 (Z)-Non-2-en-1-ol / Unkown
HY-W142921S Allyl methyl disulfide-d3 / Unkown
HY-W190911 Cyclooct-4-en-1-yl(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate / Unkown
HY-W319939 3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one Modulator / Unkown
HY-W654395 Methyl jasmonate-d5 (mixture of diastereomers) / Unkown
HY-W838865 11-Dodecenol / Unkown
HY-W923632 (Z)-Tetradec-9-en-1-ol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens En1 NCBI NCBI:2019