2. Gene
  3. Dnmt3b - DNA methyltransferase 3B Gene

Dnmt3b - DNA methyltransferase 3B Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MmuIIIB

Gene ID: 13436 | Gene type: protein coding

About Dnmt3b

Summary

This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene results in severe developmental defects and loss of viability. Mutation of the related gene in humans causes immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. There is a pseudogene for this gene located adjacent to this gene in the same region of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]

Dnmt3b Products(9)

mRNA Protein Name
NM_001003960.4 NP_001003960.2 DNA (cytosine-5)-methyltransferase 3B isoform 2
NM_001003961.4 NP_001003961.2 DNA (cytosine-5)-methyltransferase 3B isoform 1
NM_001003963.4 NP_001003963.2 DNA (cytosine-5)-methyltransferase 3B isoform 4
NM_001122997.2 NP_001116469.1 DNA (cytosine-5)-methyltransferase 3B isoform 5
NM_001271744.1 NP_001258673.1 DNA (cytosine-5)-methyltransferase 3B isoform 1
NM_001271745.1 NP_001258674.1 DNA (cytosine-5)-methyltransferase 3B isoform 2
NM_001271746.1 NP_001258675.1 DNA (cytosine-5)-methyltransferase 3B isoform 4
NM_001271747.1 NP_001258676.1 DNA (cytosine-5)-methyltransferase 3B isoform 3
NM_010068.5 NP_034198.3 DNA (cytosine-5)-methyltransferase 3B isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA (cytosine-5-)-methyltransferase activity IDA
IDA: Inferred from direct assay
9662389 MGI
enables DNA (cytosine-5-)-methyltransferase activity IGI
IGI: Inferred from genetic interaction
17938196 MGI
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates IDA
IDA: Inferred from direct assay
27856912 MGI
enables DNA binding IDA
IDA: Inferred from direct assay
21378119 MGI
enables lncRNA binding IDA
IDA: Inferred from direct assay
25686699 MGI
enables methyltransferase activity IDA
IDA: Inferred from direct assay
11919202 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11934864 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within DNA methylation-dependent heterochromatin formation IGI
IGI: Inferred from genetic interaction
17938196 MGI
acts upstream of or within autosome genomic imprinting IMP
IMP: Inferred from mutant phenotype
11934864 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
acts upstream of or within epigenetic programming of gene expression IGI
IGI: Inferred from genetic interaction
10555141 MGI
involved in epigenetic regulation of gene expression IEP
IEP: Inferred from expression pattern
18814855 MGI
acts upstream of or within gene silencing by piRNA-directed DNA methylation IDA
IDA: Inferred from direct assay
27856912 MGI
acts upstream of or within heterochromatin formation IMP
IMP: Inferred from mutant phenotype
22516971 MGI
involved in negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
18056424 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22133874 MGI
acts upstream of or within protein-containing complex localization IDA
IDA: Inferred from direct assay
16543361 MGI
acts upstream of or within retrotransposon silencing by heterochromatin formation IDA
IDA: Inferred from direct assay
27856912 MGI
Cellular Component GO Annotation Evidence Reference Source
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
15456878 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
11934864 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16543361 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA (cytosine-5)-methyltransferase 3B

DNA MTase MmuIIIB

DNA methyltransferase MmuIIIB

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13962 SGI-1027 99.77% Unkown
HY-101925 CM-272 98.70% Unkown
HY-103397 Nanaomycin A Inhibitor 98.18% Unkown
HY-124131 DS-437 Inhibitor 98.00% Unkown
HY-111544 EML741 Inhibitor / Unkown
HY-149389 PNMT-IN-1 Inhibitor / Unkown
HY-RS03912 DNMT3B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16772 Dnmt3b Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23212 Dnmt3b Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dnmt3b NCBI NCBI:1789