Dld - dihydrolipoamide dehydrogenase Gene

Mus musculus

Gene ID: 13382 | Gene type: protein coding

About Dld

Summary

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the encoded protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, this protein can function as a protease. [provided by RefSeq, Jan 2014]

Dld Products(1)

mRNA	Protein	Name
NM_007861.5	NP_031887.2	dihydrolipoyl dehydrogenase, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables dihydrolipoyl dehydrogenase activity	IMP IMP: Inferred from mutant phenotype	9405644	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	29128334	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in acetyl-CoA biosynthetic process from pyruvate	IMP IMP: Inferred from mutant phenotype	17314311	MGI
acts upstream of or within gastrulation	IMP IMP: Inferred from mutant phenotype	9405644	MGI
acts upstream of or within mitochondrial electron transport, NADH to ubiquinone	IMP IMP: Inferred from mutant phenotype	15009635	MGI
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	17404228	MGI
acts upstream of or within regulation of membrane potential	IMP IMP: Inferred from mutant phenotype	15009635	MGI
acts upstream of or within sperm capacitation	IDA IDA: Inferred from direct assay	15888450	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of acetyltransferase complex	IMP IMP: Inferred from mutant phenotype	9405644	MGI
located in acrosomal matrix	IDA IDA: Inferred from direct assay	15888450	MGI
located in cilium	IDA IDA: Inferred from direct assay	15888450	MGI
is active in mitochondrial matrix	IDA IDA: Inferred from direct assay	9405644	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	15888450	MGI
part of oxoglutarate dehydrogenase complex	IMP IMP: Inferred from mutant phenotype	15356189	MGI
part of pyruvate dehydrogenase complex	IMP IMP: Inferred from mutant phenotype	9405644	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dihydrolipoyl dehydrogenase, mitochondrial

branched chain alpha-keto acid dehydrogenase complex subunit E3

Related Agents

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122312	BAY-8002	Inhibitor	98.39%	Unkown
HY-139691	SR15006	Inhibitor	99.95%	Unkown
HY-119257	ABT-100		98.18%	Unkown
HY-156375	PKM2 activator 6		/	Unkown
HY-169652	NPC26	Activator	≥98.0%	Unkown
HY-120667	DS-5272		/	Unkown
HY-118829	3,4-Methylenedioxy PV9 hydrochloride		99.90%	Unkown
HY-161654	PROTAC SOS1 degrader-10		/	Unkown
HY-163816	Antiproliferative agent-53-d3	Inhibitor	/	Unkown
HY-168716	SOS1-IN-17	Inhibitor	/	Unkown
HY-168733	LDHA-IN-9		/	Unkown
HY-RS03794	DLD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121619	Jacaric acid	Inducer	/	Unkown
HY-122063	FR260330	Inhibitor	/	Unkown
HY-N13886	Anicequol		/	Unkown
HY-N7305	Jatrophane 5	Inhibitor	/	Unkown
HY-RS19107	Dld Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25597	Dld Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dld	NCBI	NCBI:1738

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