2. Gene
  3. Des - desmin Gene

Des - desmin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 13346 | Gene type: protein coding

About Des

Summary

This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each Other and to the plasma membrane and are essential for maintaining the strength and integrity of skeletal, cardiac and smooth muscle fibers. Mutations in this gene affect assembly of intermediate filaments. Mice lacking this gene are able to develop and reproduce but exhibit abnormal muscle fibers. Mutations in the human gene are associated with myofibrillar myopathy, dilated cardiomyopathy, neurogenic scapuloperoneal syndrome and autosomal recessive limb-girdle muscular dystrophy, type 2R. [provided by RefSeq, Jan 2014]

Des Products(1)

mRNA Protein Name
NM_010043.2 NP_034173.1 desmin
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11694502 MGI
Biological Process GO Annotation Evidence Reference Source
involved in nuclear envelope organization IMP
IMP: Inferred from mutant phenotype
35959657 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Z disc IDA
IDA: Inferred from direct assay
10532952 MGI
located in cell tip IDA
IDA: Inferred from direct assay
35959657 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
24532688 MGI
located in contractile muscle fiber IDA
IDA: Inferred from direct assay
14627610 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
21177767 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
11694502 MGI
located in fascia adherens IDA
IDA: Inferred from direct assay
11732910 MGI
colocalizes with intermediate filament IDA
IDA: Inferred from direct assay
16917092 MGI
located in neuromuscular junction IDA
IDA: Inferred from direct assay
11694502 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
35959657 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26787680 MGI
located in sarcolemma IDA
IDA: Inferred from direct assay
11694502 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

desmin

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14598 Diethylstilbestrol 99.62% Unkown
HY-P0048 (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH Agonist 99.45% Unkown
Pre-clinical Phase
Bioactive Molecules (56)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P0298A [Des-Arg9]-Bradykinin acetate Agonist 99.95% Unkown
HY-P1366 des-​Gln14-​Ghrelin 99.66% Unkown
HY-P1143A [Des-His1,Glu9]-Glucagon amide TFA Antagonist 99.62% Unkown
HY-122402 Umirolimus 99.35% Unkown
HY-N9542 Dimethyl Citric acid ≥97.0% Unkown
HY-103291 Sar-[D-Phe8]-des-Arg9-Bradykinin Agonist 99.96% Unkown
HY-103295A Lys-[Des-Arg9]Bradykinin TFA Agonist 99.43% Unkown
HY-W040270 Amino-PEG10-amine ≥97.0% Unkown
HY-130411 Amino-PEG11-amine ≥95.0% Unkown
HY-P1490 Bradykinin (2-9) Modulator 97.15% Unkown
HY-P0298 [Des-Arg9]-Bradykinin Agonist / Unkown
HY-P2828 [Des-Pro2]-Bradykinin Inhibitor 99.68% Unkown
HY-P4676 Lys-(Des-Arg9,Leu8)-Bradykinin Antagonist 98.23% Unkown
HY-P4683 (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin Antagonist / Unkown
HY-P4683A (Phenylac1,D-Tyr(Et)2,Lys6,Arg8,des-Gly9)-Vasopressin acetate Antagonist 99.81% Unkown
HY-N11758 5′-Des-O-methylharringtonine 99.80% Unkown
HY-P5518A [Des-Arg10]-HOE I40 TFA Antagonist / Unkown
HY-132795S Des(1-cyclohexanol) Venlafaxine-d6 / Unkown
HY-141757S Des-p-fluorobenzyl mosapride-d5 / Unkown
HY-103295 Lys-[Des-Arg9]Bradykinin Agonist / Unkown
HY-15899 Des(benzylpyridyl) Atazanavir Inhibitor / Unkown
HY-163472 PR280 Inhibitor / Unkown
HY-CE00411 (S)-Des-Me-ampa-CoA / Unkown
HY-D1346 610CP / Unkown
HY-P10498 [Des-Tyr1]-gamma-Endorphin / Unkown
HY-P1143 [Des-His1,Glu9]-Glucagon amide Antagonist / Unkown
HY-P1366A des-​Gln14-​Ghrelin TFA / Unkown
HY-P1526 ANP [Des18-22] 4-23 amide (rat) Ligand / Unkown
HY-P2088 TANDEM / Unkown
HY-P2658 [Des-Tyr1]-Met-Enkephalin / Unkown
HY-P3006 Des-Leu10-angiotensin I / Unkown
HY-P3209 Des-Arg9-[Leu8]-Bradykinin acetate Inhibitor / Unkown
HY-P3542 Des His1, Glu8 Exendin-4 Antagonist / Unkown
HY-P3583 (Des-Gly10,D-Arg6,Pro-NHEt9)-LHRH II (chicken) / Unkown
HY-P3608 [Des-His1,Glu9] Glucagon Antagonist / Unkown
HY-P4397 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin / Unkown
HY-P4413 (Des-Glu5)-ACTH (1-24) (human, bovine, rat) / Unkown
HY-P4414 (Des-Bromo)-Neuropeptide B (1-23) (human) Agonist / Unkown
HY-P4432 (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH (salmon) Activator / Unkown
HY-P4440 (Des-Gly10,Des-Ser4,D-Leu6,Pro-NHEt9)-LHRH / Unkown
HY-P4441 (Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH / Unkown
HY-P4442 (Des-Gly10,D-His2,D-Trp6,Pro-NHEt9)-LHRH / Unkown
HY-P4445 (Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH / Unkown
HY-P4447 (Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH / Unkown
HY-P4456 (Des-His6)-ACTH (1-24) (human, bovine, rat) / Unkown
HY-P4459 (Des-Gly2)-Exenatide Control / Unkown
HY-P4463 (Des-Pyr1)-LHRH / Unkown
HY-P4467 (Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH / Unkown
HY-P4541 (D-Phe6,Leu-NHEt13,des-Met14)-Bombesin (6-14) Antagonist / Unkown
HY-P5518 [Des-Arg10]-HOE I40 Antagonist / Unkown
HY-P5713 Des(8-14)brevinin-1PMa Inhibitor / Unkown
HY-RS03703 DES Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-169836 Des-ethyl-carafiban / Unkown
HY-RS17101 Des Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23545 Des Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-Z6430 Des-4-fluorobenzyl mosapride Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Des NCBI NCBI:1674
Rattus norvegicus Des NCBI NCBI:64362