Ddx4 - DEAD box helicase 4 Gene

Mus musculus

Also known as Mvh; VASA

Gene ID: 13206 | Gene type: protein coding

About Ddx4

Summary

Predicted to enable RNA binding activity and RNA helicase activity. Involved in gamete generation; negative regulation of transposition; and piRNA biosynthetic process. Acts upstream of or within male meiosis I and regulation of protein localization. Located in cytoplasmic ribonucleoprotein granule; nucleus; and perinuclear region of cytoplasm. Part of ribonucleoprotein complex. Is expressed in alimentary system mesentery; primordial germ cell; reproductive system; surface ectoderm; and urogenital ridge. Orthologous to human DDX4 (DEAD-box helicase 4). [provided by Alliance of Genome Resources, Apr 2022]

Ddx4 Products(2)

mRNA	Protein	Name
NM_001145885.1	NP_001139357.1	ATP-dependent RNA helicase DDX4 isoform 1
NM_010029.2	NP_034159.1	ATP-dependent RNA helicase DDX4 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IMP IMP: Inferred from mutant phenotype	28633017	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14648869	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within male meiosis I	IMP IMP: Inferred from mutant phenotype	10766740	MGI
involved in male meiosis I	IMP IMP: Inferred from mutant phenotype	28633017	MGI
involved in male meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	20439430	MGI
involved in piRNA processing	IMP IMP: Inferred from mutant phenotype	20439430	MGI
acts upstream of positive effect piRNA-mediated retrotransposon silencing by heterochromatin formation	IMP IMP: Inferred from mutant phenotype	28633017	MGI
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	17141210	MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation	IMP IMP: Inferred from mutant phenotype	20439430	MGI
involved in secondary piRNA processing	IMP IMP: Inferred from mutant phenotype	28633017	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	10766740	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	20439430	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatoid body	IDA IDA: Inferred from direct assay	10781947	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	10781947	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12798292	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10781947	MGI
located in pi-body	IDA IDA: Inferred from direct assay	20011505	MGI
located in piP-body	IDA IDA: Inferred from direct assay	20011505	MGI
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17141210	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DDX4

D-E-A-D (aspartate-glutamate-alanine-aspartate) box polypeptide 4	DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 4	DEAD box polypeptide 4
DEAD box protein 4	DEAD/H (Asp-Glu-Ala-Asp/His) box polyp

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03648	DDX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22135	Ddx4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ddx4	NCBI	NCBI:54514

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