2. Gene
  3. Cyp24a1 - cytochrome P450, family 24, subfamily a, polypeptide 1 Gene

Cyp24a1 - cytochrome P450, family 24, subfamily a, polypeptide 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CP24; Cyp24; 24-OHase

Gene ID: 13081 | Gene type: protein coding

About Cyp24a1

Summary

The protein encoded by this gene localizes to the mitochondrion, where it degrades calcitriol to calcitetrol. This gene is upregulated by binding of calcitriol to the upstream regulatory region and to a downstream enhancer region, thereby allowing calcitriol to autoregulate its concentration in the cell. The encoded protein may also play a role in calcium homeostasis. [provided by RefSeq, Aug 2015]

Cyp24a1 Products(1)

mRNA Protein Name
NM_009996.4 NP_034126.1 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables 25-hydroxycholecalciferol-24-hydroxylase activity IMP
IMP: Inferred from mutant phenotype
15225763 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within vitamin D metabolic process IMP
IMP: Inferred from mutant phenotype
15225763 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial

25-hydroxyvitamin D-24-hydroxylase

cytochrome P450 24A1

cytochrome P450, 24

cytochrome P450, 24a1

cytochrome P450-CC24

vitamin D(3) 24-hydroxylase

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0105 Ketoconazole Inhibitor 99.51% Yes
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-77278 25-Hydroxytachysterol3 Agonist 98.89% Unkown
HY-B0105S1 Ketoconazole-d4 Inhibitor 99.63% Unkown
HY-B0105S Ketoconazole-d8 Inhibitor 99.79% Unkown
HY-RS03446 CYP24A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-166670S Ketoconazole carbonyl-13C Inhibitor / Unkown
HY-RS19541 Cyp24a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26037 Cyp24a1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp24a1 NCBI NCBI:1591