Cyp1b1 - cytochrome P450, family 1, subfamily b, polypeptide 1 Gene

Mus musculus

Also known as CP1B; CYPIB1; P4501b1

Gene ID: 13078 | Gene type: protein coding

About Cyp1b1

Summary

Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Involved in several processes, including camera-type eye development; cellular response to oxidative stress; and retinoid metabolic process. Acts upstream of or within several processes, including endothelial cell-cell adhesion; toxin metabolic process; and vasculature development. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; musculature; nervous system; and sensory organ. Used to study buphthalmos. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (Cytochrome P450 family 1 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp1b1 Products(2)

mRNA	Protein	Name
NM_001364889.1	NP_001351818.1	cytochrome P450 1B1 isoform 2
NM_009994.2	NP_034124.1	cytochrome P450 1B1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monooxygenase activity	IDA IDA: Inferred from direct assay	15258110	MGI
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA IDA: Inferred from direct assay	9367523	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	19005183	MGI
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	15258110	MGI
acts upstream of or within benzene-containing compound metabolic process	IDA IDA: Inferred from direct assay	1910294	MGI
acts upstream of or within benzene-containing compound metabolic process	IMP IMP: Inferred from mutant phenotype	9367523	MGI
acts upstream of or within blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	19005183	MGI
involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	23568032	MGI
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	23979599	MGI
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	23979599	MGI
involved in collagen fibril organization	IMP IMP: Inferred from mutant phenotype	23979599	MGI
NOT acts upstream of or within dibenzo-p-dioxin metabolic process	IMP IMP: Inferred from mutant phenotype	16636061	MGI
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	20032512	MGI
acts upstream of or within endothelial cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	19005183	MGI
involved in estrogen metabolic process	IDA IDA: Inferred from direct assay	23821647	MGI
involved in intrinsic apoptotic signaling pathway in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	23568032	MGI
involved in membrane lipid catabolic process	IMP IMP: Inferred from mutant phenotype	19005183	MGI
involved in negative regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	23568032	MGI
involved in negative regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	23568032	MGI
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	23568032	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23568032	MGI
involved in nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	20032512	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	20032512	MGI
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23568032	MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	23568032	MGI
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	23568032	MGI
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	19005183	MGI
acts upstream of or within response to toxic substance	IMP IMP: Inferred from mutant phenotype	16377763	MGI
acts upstream of or within retina vasculature development in camera-type eye	IMP IMP: Inferred from mutant phenotype	19005183	MGI
involved in retinal blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	20032512	MGI
involved in retinal metabolic process	IDA IDA: Inferred from direct assay	15258110	MGI
involved in retinol metabolic process	IDA IDA: Inferred from direct assay	15258110	MGI
acts upstream of or within toxin metabolic process	IMP IMP: Inferred from mutant phenotype	10051580	MGI
involved in trabecular meshwork development	IMP IMP: Inferred from mutant phenotype	23979599	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	23692925	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytochrome P450 1B1

cytochrome P450, 1b1, benz[a]anthracene inducible	cytochrome P450CMEF
cytochrome P450EF	hydroperoxy icosatetraenoate dehydratase

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1234	Octinoxate		99.84%	Unkown
HY-W017113	2-Mercaptobenzothiazole	Activator	99.85%	Yes

Pre-clinical Phase

Bioactive Molecules (29)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19340	TMS	Inhibitor	99.40%	Unkown
HY-W007700	8-Bromooctanoic acid		99.89%	Unkown
HY-101284	DMU2105	Inhibitor	99.54%	Unkown
HY-152118	CYP1B1-IN-4	Inhibitor	99.09%	Unkown
HY-101285	DMU2139	Inhibitor	≥98.0%	Unkown
HY-159006	CYP1B1 ligand 3	Inhibitor	99.83%	Unkown
HY-146393	PROTAC CYP1B1 degrader-1	Inhibitor	98.09%	Unkown
HY-RS03443	CYP1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-157942	CYP1B1-IN-7	Inhibitor	99.88%	Unkown
HY-150557	CYP1B1-IN-1	Inhibitor	/	Unkown
HY-150558	CYP1B1-IN-2	Inhibitor	/	Unkown
HY-152079	CYP1B1-IN-3	Inhibitor	/	Unkown
HY-152196	CYP1B1-IN-5	Inhibitor	/	Unkown
HY-158429	PROTAC CYP1B1 degrader-2	Degrader	/	Unkown
HY-158430	CYP1B1 ligand 2		/	Unkown
HY-161403	CYP1B1-IN-8	Inhibitor	/	Unkown
HY-162051	CYP1B1-IN-6	Inhibitor	/	Unkown
HY-174425	CYP1B1-IN-9	Inhibitor	/	Unkown
HY-E70476	Human CYP1B1,Low-Reductase		/	Unkown
HY-W713284	2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate		/	Unkown
HY-101284A	(E/Z)-DMU2105	Inhibitor	/	Unkown
HY-126308	(E/Z)-DMU2139	Inhibitor	/	Unkown
HY-158431	(S,R,S)-AHPC-Me-8-bromooctanoic acid		/	Unkown
HY-B1234S	Octinoxate-13C,d3		/	Unkown
HY-RS16945	Cyp1b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23388	Cyp1b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W472509	11-HETE	Activator	/	Unkown
HY-W517092	1,2,3,4,7,8,9-Heptachlorodibenzofuran		/	Unkown
HY-W775354	1,2,3,4,7,8-Hexachlorodibenzofuran		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyp1b1	NCBI	NCBI:1545

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