2. Gene
  3. Cyp11b2 - cytochrome P450, family 11, subfamily b, polypeptide 2 Gene

Cyp11b2 - cytochrome P450, family 11, subfamily b, polypeptide 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cpn2; ALDOS; Cyp11b; Cyp11b-2

Gene ID: 13072 | Gene type: protein coding

About Cyp11b2

Summary

Enables steroid 11-beta-monooxygenase activity. Acts upstream of or within several processes, including aldosterone biosynthetic process; drinking behavior; and regulation of systemic arterial blood pressure by hormone. Located in mitochondrion. Is expressed in adrenal gland and gland. Human ortholog(s) of this gene implicated in several diseases, including congenital adrenal hyperplasia; corticosterone methyloxidase deficiency 1; diabetes mellitus (multiple); hypertension (multiple); and primary hyperaldosteronism (multiple). Orthologous to several human genes including CYP11B2 (Cytochrome P450 family 11 subfamily B member 2). [provided by Alliance of Genome Resources, Apr 2022]

Cyp11b2 Products(1)

mRNA Protein Name
NM_009991.4 NP_034121.4 cytochrome P450 11B2, mitochondrial
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables steroid 11-beta-monooxygenase activity IDA
IDA: Inferred from direct assay
1686470 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within aldosterone biosynthetic process IDA
IDA: Inferred from direct assay
1686470 MGI
acts upstream of or within drinking behavior IMP
IMP: Inferred from mutant phenotype
16118390 MGI
acts upstream of or within monoatomic ion homeostasis IMP
IMP: Inferred from mutant phenotype
16118390 MGI
acts upstream of or within regulation of blood volume by renal aldosterone IMP
IMP: Inferred from mutant phenotype
16118390 MGI
acts upstream of or within regulation of systemic arterial blood pressure by circulatory renin-angiotensin IMP
IMP: Inferred from mutant phenotype
16118390 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 11B2, mitochondrial

aldosterone synthase

aldosterone-synthesizing enzyme

corticosterone 18-monooxygenase, CYP11B2

cytochrome P-450Aldo

cytochrome P-450C18

cytochrome P450C11

steroid 11-beta-hydroxylase, CYP11B2

steroid 18-hydroxylase

steroid-11-beta-hydroxylase

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16276 Osilodrostat Inhibitor 99.90% Yes
HY-16276A Osilodrostat phosphate Inhibitor 99.35% Yes
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-19833 Lapiteronel Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113151 18-Oxocortisol Antagonist 99.86% Unkown
HY-155493 CYP19A1/CYP11B2-IN-1 Inhibitor 99.85% Unkown
HY-101217 BI 689648 Inhibitor 99.20% Unkown
HY-135281 CYP11B2-IN-1 Inhibitor 99.83% Unkown
HY-176480 CYP11B2-IN-3 Inhibitor / Unkown
HY-RS03436 CYP11B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-162574 CYP11B2-IN-2 Inhibitor / Unkown
HY-163751 STING-IN-9 Inhibitor / Unkown
HY-RS17177 Cyp11b2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23627 Cyp11b2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W002108 3,4-Dihydroquinolin-2(1H)-one ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp11b2 NCBI NCBI:1585