2. Gene
  3. Col5a2 - collagen, type V, alpha 2 Gene

Col5a2 - collagen, type V, alpha 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 1110014L14Rik

Gene ID: 12832 | Gene type: protein coding

About Col5a2

Summary

This gene encodes the alpha-2 subunit of type V Collagen, one of the low abundance fibrillar collagens that gets incorporated into growing fibrils with type I Collagen. The encoded protein, in association with alpha-1 and/or alpha-3 subunits, forms homo- or heterotrimeric type V procollagen that undergoes proteolytic processing. Mice lacking the encoded protein die in utero. Transgenic mice that produce a structurally abnormal form of the encoded protein survive poorly and exhibit skin fragility, skeletal abnormalities and alterations in the Collagen fiber organization. [provided by RefSeq, Dec 2015]

Col5a2 Products(1)

mRNA Protein Name
NM_007737.2 NP_031763.2 collagen alpha-2(V) chain preproprotein
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SMAD binding IPI
IPI: Inferred from physical interaction
14559231 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
involved in collagen fibril organization IMP
IMP: Inferred from mutant phenotype
15199158 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
7704020 MGI
involved in skin development IMP
IMP: Inferred from mutant phenotype
15199158 MGI
Cellular Component GO Annotation Evidence Reference Source
part of collagen trimer IDA
IDA: Inferred from direct assay
7704020 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-2(V) chain

procollagen, type V, alpha 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02990 COL5A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21839 Col5a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28355 Col5a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col5a2 NCBI NCBI:1290