2. Gene
  3. Chrm1 - cholinergic receptor, muscarinic 1, CNS Gene

Chrm1 - cholinergic receptor, muscarinic 1, CNS Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as M1; M1R; Chrm-1

Gene ID: 12669 | Gene type: protein coding

About Chrm1

Summary

Enables neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential. Acts upstream of or within regulation of locomotion. Located in cholinergic synapse. Is active in Schaffer collateral - CA1 synapse. Is integral component of postsynaptic membrane. Is expressed in central nervous system; retina; and urinary system. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome; asthma; and myasthenia gravis. Orthologous to human CHRM1 (cholinergic receptor muscarinic 1). [provided by Alliance of Genome Resources, Apr 2022]

Chrm1 Products(2)

mRNA Protein Name
NM_001112697.1 NP_001106167.1 muscarinic acetylcholine receptor M1
NM_007698.3 NP_031724.2 muscarinic acetylcholine receptor M1
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in postsynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
26472558 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
26472558 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
26472558 MGI
acts upstream of or within regulation of locomotion IMP
IMP: Inferred from mutant phenotype
11752469 MGI
involved in regulation of postsynaptic membrane potential EXP
EXP: Inferred from Experiment
26472558 MGI
involved in regulation of postsynaptic membrane potential IDA
IDA: Inferred from direct assay
26472558 MGI
involved in regulation of postsynaptic membrane potential IMP
IMP: Inferred from mutant phenotype
26472558 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
26472558 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
26472558 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
26472558 MGI
is active in cholinergic synapse IDA
IDA: Inferred from direct assay
20335477 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
20335477 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

muscarinic acetylcholine receptor M1

AChR M1

m1 muscarinic acetylcholine receptor protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02660 CHRM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18169 Chrm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24643 Chrm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Chrm1 NCBI NCBI:1128
Rattus norvegicus Chrm1 NCBI NCBI:25229