Cdx2 - caudal type homeobox 2 Gene

Mus musculus

Also known as Cdx-2

Gene ID: 12591 | Gene type: protein coding

About Cdx2

Summary

Enables DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in intestinal epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of somitogenesis. Acts upstream of or within several processes, including endosome to lysosome transport; establishment or maintenance of epithelial cell apical/basal polarity; and in utero embryonic development. Located in condensed nuclear chromosome. Part of transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; embryo mesoderm; genitourinary system; and gut. Orthologous to human CDX2 (caudal type homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Cdx2 Products(1)

mRNA	Protein	Name
NM_007673.3	NP_031699.2	homeobox protein CDX-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16325584	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	9512360	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16325584	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19796622	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior/posterior pattern specification	IGI IGI: Inferred from genetic interaction	19853565	MGI
acts upstream of or within blastocyst development	IMP IMP: Inferred from mutant phenotype	15788452	MGI
acts upstream of or within blood vessel development	IGI IGI: Inferred from genetic interaction	16396910	MGI
acts upstream of or within endosome to lysosome transport	IMP IMP: Inferred from mutant phenotype	20551175	MGI
acts upstream of or within establishment or maintenance of epithelial cell apical/basal polarity	IMP IMP: Inferred from mutant phenotype	20551175	MGI
involved in intestinal epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	22015720	MGI
acts upstream of or within labyrinthine layer development	IGI IGI: Inferred from genetic interaction	19853565	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16325584	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16325584	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	11959827	MGI
acts upstream of or within placenta development	IGI IGI: Inferred from genetic interaction	16396910	MGI
acts upstream of or within positive regulation of cell differentiation	IDA IDA: Inferred from direct assay	16325584	MGI
acts upstream of or within positive regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	22190642	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9512360	MGI
involved in regulation of somitogenesis	IMP IMP: Inferred from mutant phenotype	22015720	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19796622	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	16325584	MGI
acts upstream of or within stem cell differentiation	IMP IMP: Inferred from mutant phenotype	20404091	MGI
acts upstream of trophectodermal cell differentiation	IDA IDA: Inferred from direct assay	16325584	MGI
acts upstream of or within trophectodermal cell differentiation	IDA IDA: Inferred from direct assay	16325584	MGI
acts upstream of or within trophectodermal cell differentiation	IMP IMP: Inferred from mutant phenotype	15788452	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	15509711	MGI
located in nucleus	IDA IDA: Inferred from direct assay	16325584	MGI
part of protein-containing complex	IDA IDA: Inferred from direct assay	19796622	MGI
part of transcription repressor complex	IDA IDA: Inferred from direct assay	16325584	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

homeobox protein CDX-2

caudal type homeo box 2

caudal-type homeobox protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1727	Super-TDU	Antagonist	99.65%	Unkown
HY-P1727A	Super-TDU TFA	Antagonist	/	Unkown
HY-RS02430	CDX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18606	Cdx2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25092	Cdx2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdx2	NCBI	NCBI:1045

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