Cbx5 - chromobox 5 Gene

Mus musculus

Also known as HP1; Hp1a; Hp1alpha; 2610029O15Rik

Gene ID: 12419 | Gene type: protein coding

About Cbx5

Summary

Enables several functions, including histone deacetylase binding activity; identical protein binding activity; and methylated histone binding activity. Acts upstream of or within negative regulation of transcription, DNA-templated. Located in chromocenter; chromosomal region; and nucleolus. Part of histone deacetylase complex; Histone Methyltransferase complex; and transcription repressor complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human CBX5 (chromobox 5). [provided by Alliance of Genome Resources, Apr 2022]

Cbx5 Products(4)

mRNA	Protein	Name
NM_001076789.2	NP_001070257.1	chromobox protein homolog 5
NM_001110216.1	NP_001103686.1	chromobox protein homolog 5
NM_001358950.1	NP_001345879.1	chromobox protein homolog 5
NM_007626.3	NP_031652.1	chromobox protein homolog 5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12242305	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	10318760	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	12242305	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	8978696	MGI
enables methylated histone binding	IPI IPI: Inferred from physical interaction	16127177	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8978696	MGI
enables protein-macromolecule adaptor activity	IPI IPI: Inferred from physical interaction	12242305	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10562550	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromocenter	IDA IDA: Inferred from direct assay	17284516	MGI
located in chromosome, telomeric region	IDA IDA: Inferred from direct assay	20110566	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	10318760	MGI
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	12242305	MGI
part of histone methyltransferase complex	IDA IDA: Inferred from direct assay	12242305	MGI
located in kinetochore	IDA IDA: Inferred from direct assay	14519686	MGI
located in nucleolus	IDA IDA: Inferred from direct assay	10318760	MGI
located in nucleus	IDA IDA: Inferred from direct assay	10318760	MGI
located in pericentric heterochromatin	IDA IDA: Inferred from direct assay	20110566	MGI
part of transcription repressor complex	IDA IDA: Inferred from direct assay	12242305	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

chromobox protein homolog 5

HP1 alpha	chromobox homolog 5
heterochromatin protein 1 alpha	heterochromatin protein 1 homolog alpha
mHP1(alpha)

Cbx5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Cbx5	Q61686	Senp7	Mus musculus	Q8BUH8	Anti Tag CoIP	22388734
Intra	Cbx5	Q61686	Trim24	Mus musculus	Q64127	Y2H	8978696

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-142952	UNC6864 (Kei)	Inhibitor	/	Unkown
HY-142953	UNC6349 (Ket2)	Inhibitor	/	Unkown
HY-142954	UNC6212 (Kme2)	Inhibitor	/	Unkown
HY-RS02012	CBX5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cbx5	NCBI	NCBI:23468

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