2. Gene
  3. Cacna1c - calcium channel, voltage-dependent, L type, alpha 1C subunit Gene

Cacna1c - calcium channel, voltage-dependent, L type, alpha 1C subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as MBC; Cav1.2; Cchl1a1; MELC-CC; D930026N18Rik

Gene ID: 12288 | Gene type: protein coding

About Cacna1c

Summary

Enables enzyme binding activity; voltage-gated Calcium Channel activity involved in cardiac muscle cell action potential; and voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in positive regulation of Adenylate Cyclase activity. Acts upstream of or within several processes, including adult walking behavior; regulation of blood circulation; and secretion by cell. Located in several cellular components, including T-tubule; Z disc; and dendritic shaft. Part of caveolar macromolecular signaling complex. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and heart. Used to study Timothy syndrome. Human ortholog(s) of this gene implicated in Brugada syndrome 3 and Timothy syndrome. Orthologous to human CACNA1C (calcium voltage-gated channel subunit alpha1 C). [provided by Alliance of Genome Resources, Apr 2022]

Cacna1c Products(11)

mRNA Protein Name
NM_001159533.2 NP_001153005.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 2
NM_001159534.2 NP_001153006.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 3
NM_001159535.2 NP_001153007.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 4
NM_001255997.2 NP_001242926.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 5
NM_001255998.2 NP_001242927.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 6
NM_001255999.2 NP_001242928.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 7
NM_001256000.2 NP_001242929.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 8
NM_001256001.2 NP_001242930.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 9
NM_001256002.2 NP_001242931.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 10
NM_001290335.1 NP_001277264.1 voltage-dependent L-type calcium channel subunit alpha-1C isoform 11
NM_009781.4 NP_033911.2 voltage-dependent L-type calcium channel subunit alpha-1C isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
21670503 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16352659 MGI
enables voltage-gated calcium channel activity IDA
IDA: Inferred from direct assay
1385406 MGI
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
10973973 MGI
enables voltage-gated calcium channel activity involved in cardiac muscle cell action potential IDA
IDA: Inferred from direct assay
32109384 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within adult walking behavior IGI
IGI: Inferred from genetic interaction
9882694 MGI
acts upstream of or within calcium ion import across plasma membrane IDA
IDA: Inferred from direct assay
32109384 MGI
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
7635187 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
15132976 MGI
acts upstream of or within calcium-ion regulated exocytosis IMP
IMP: Inferred from mutant phenotype
12881419 MGI
acts upstream of or within cell communication involved in cardiac conduction IDA
IDA: Inferred from direct assay
32109384 MGI
acts upstream of or within chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
16251435 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
32109384 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
12881419 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
12881419 MGI
acts upstream of or within growth hormone secretion IDA
IDA: Inferred from direct assay
1385406 MGI
acts upstream of or within insulin secretion IMP
IMP: Inferred from mutant phenotype
12881419 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
15132976 MGI
involved in positive regulation of adenylate cyclase activity IDA
IDA: Inferred from direct assay
24086669 MGI
acts upstream of or within regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
14609949 MGI
acts upstream of or within regulation of organ growth IMP
IMP: Inferred from mutant phenotype
15132976 MGI
acts upstream of or within regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
14609949 MGI
acts upstream of or within smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
16636102 MGI
acts upstream of or within smooth muscle contraction involved in micturition IMP
IMP: Inferred from mutant phenotype
15132976 MGI
acts upstream of or within visual learning IMP
IMP: Inferred from mutant phenotype
16251435 MGI
Cellular Component GO Annotation Evidence Reference Source
located in T-tubule IDA
IDA: Inferred from direct assay
22355118 MGI
located in Z disc IDA
IDA: Inferred from direct assay
19383796 MGI
part of caveolar macromolecular signaling complex IDA
IDA: Inferred from direct assay
16648270 MGI
located in dendritic shaft IDA
IDA: Inferred from direct assay
15090038 MGI
located in membrane IDA
IDA: Inferred from direct assay
15132976 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
15090038 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
7598723 MGI
part of voltage-gated calcium channel complex IMP
IMP: Inferred from mutant phenotype
3315915 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit alpha-1C

brain class C

calcium channel voltage-dependent alpha1c subunit

neuronal voltage-gated calcium channel alpha 1C subunit

skeletal muscle-specific calcium channel

voltage-gated calcium channel subunit alpha Cav1.2

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01793 CACNA1C Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21233 Cacna1c Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacna1c NCBI NCBI:775