Brca2 - breast cancer 2, early onset Gene

Mus musculus

Also known as Fancd1; RAB163

Gene ID: 12190 | Gene type: protein coding

About Brca2

Summary

Predicted to enable several functions, including gamma-tubulin binding activity; Histone Acetyltransferase activity; and protein C-terminus binding activity. Involved in several processes, including establishment of protein localization to telomere; male meiosis I; and telomere maintenance via recombination. Acts upstream of or within several processes, including DNA metabolic process; gamete generation; and signal transduction by p53 class mediator. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and hemolymphoid system gland. Used to study Fanconi anemia complementation group D1 and breast Cancer. Human ortholog(s) of this gene implicated in several diseases, including Fanconi anemia (multiple); brain Cancer (multiple); hereditary breast ovarian Cancer syndrome; melanoma (multiple); and reproductive organ Cancer (multiple). Orthologous to human BRCA2 (BRCA2 DNA repair associated). [provided by Alliance of Genome Resources, Apr 2022]

Brca2 Products(2)

mRNA	Protein	Name
NM_001081001.2	NP_001074470.1	breast cancer type 2 susceptibility protein homolog
NM_009765.3	NP_033895.2	breast cancer type 2 susceptibility protein homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9126738	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	12410562	MGI
acts upstream of or within DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IMP IMP: Inferred from mutant phenotype	8738145	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	17476307	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	9171368	MGI
acts upstream of or within cellular senescence	IMP IMP: Inferred from mutant phenotype	9699678	MGI
acts upstream of or within chordate embryonic development	IMP IMP: Inferred from mutant phenotype	9171368	MGI
acts upstream of or within chromosome organization	IMP IMP: Inferred from mutant phenotype	9660919	MGI
acts upstream of or within double-strand break repair	IMP IMP: Inferred from mutant phenotype	9398843	MGI
acts upstream of or within double-strand break repair via homologous recombination	IMP IMP: Inferred from mutant phenotype	15485900	MGI
involved in establishment of protein localization to telomere	IDA IDA: Inferred from direct assay	21076401	MGI
acts upstream of or within female gonad development	IMP IMP: Inferred from mutant phenotype	9398843	MGI
acts upstream of or within hematopoietic stem cell proliferation	IMP IMP: Inferred from mutant phenotype	16859999	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	16859999	MGI
acts upstream of or within inner cell mass cell proliferation	IMP IMP: Inferred from mutant phenotype	9171369	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage	IGI IGI: Inferred from genetic interaction	17476307	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI IGI: Inferred from genetic interaction	17476307	MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP IMP: Inferred from mutant phenotype	15735671	MGI
involved in male meiosis I	IDA IDA: Inferred from direct assay	32345962	MGI
acts upstream of or within male meiosis I	IMP IMP: Inferred from mutant phenotype	14660434	MGI
acts upstream of or within oocyte maturation	IMP IMP: Inferred from mutant phenotype	14660434	MGI
acts upstream of or within positive regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	9660919	MGI
acts upstream of or within regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	15375219	MGI
acts upstream of or within replication fork processing	IMP IMP: Inferred from mutant phenotype	14681210	MGI
acts upstream of or within response to UV-C	IMP IMP: Inferred from mutant phenotype	9660919	MGI
acts upstream of or within response to X-ray	IMP IMP: Inferred from mutant phenotype	9398843	MGI
acts upstream of or within response to gamma radiation	IMP IMP: Inferred from mutant phenotype	9126738	MGI
acts upstream of or within spermatogenesis	IMP IMP: Inferred from mutant phenotype	9398843	MGI
acts upstream of or within stem cell proliferation	IMP IMP: Inferred from mutant phenotype	9398843	MGI
involved in telomere maintenance via recombination	IGI IGI: Inferred from genetic interaction	21076401	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome	IDA IDA: Inferred from direct assay	30760716	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11172592	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11172592	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

breast cancer type 2 susceptibility protein homolog

fanconi anemia group D1 protein homolog

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10617A	Rucaparib	Inhibitor	99.97%	Unkown
HY-10617	Rucaparib phosphate	Inhibitor	99.76%	Yes
HY-102003	Rucaparib monocamsylate	Inhibitor	99.82%	Yes
HY-102003A	Rucaparib camsylate	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-115552	Simmiparib	Inhibitor	99.01%	Phase 1

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-151462	RP-6685	Inhibitor	99.96%	Unkown
HY-124691	D-I03	Inhibitor	99.70%	Unkown
HY-150147	CAM833		99.83%	Unkown
HY-148183	Homologous recombination-IN-1	Inhibitor	99.65%	Unkown
HY-122639	ZINC05007751		99.33%	Unkown
HY-161431	RTx-152		99.71%	Unkown
HY-162706	BSJ-5-63	Degrader	99.97%	Unkown
HY-170844	MU147	Inhibitor	99.35%	Unkown
HY-170845	MU1409	Inhibitor	98.52%	Unkown
HY-RS01594	BRCA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-122583	D-G23	Inhibitor	/	Unkown
HY-150958	RAD51-IN-8		/	Unkown
HY-155766	PARP1-IN-14		/	Unkown
HY-163816	Antiproliferative agent-53-d3	Inhibitor	/	Unkown
HY-168094	PARP1-IN-30	Inhibitor	/	Unkown
HY-168993	BRCA2-IN-2	Inhibitor	/	Unkown
HY-173151	BRCA2-IN-1	Inhibitor	/	Unkown
HY-173345	BRCA2-RAD51-IN-2	Inhibitor	/	Unkown
HY-P10516	BRC4 peptide		/	Unkown
HY-162104	BRCA2-RAD51-IN-1	Inhibitor	/	Unkown
HY-RS16825	Brca2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23267	Brca2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Brca2	NCBI	NCBI:675

Name
Email *

	Sorry, but the email address you supplied was invalid.