Bmp6 - bone morphogenetic protein 6 Gene

Mus musculus

Also known as Vgr1; D13Wsu115e

Gene ID: 12161 | Gene type: protein coding

About Bmp6

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Mice lacking this gene exhibit delayed ossification of the sternum, iron overload, and reduced fertility in females. [provided by RefSeq, Jul 2016]

Bmp6 Products(1)

mRNA	Protein	Name
NM_007556.4	NP_031582.1	bone morphogenetic protein 6 preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12897139	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	14623234	MGI
involved in cellular response to iron ion	IMP IMP: Inferred from mutant phenotype	19252488	MGI
acts upstream of or within endochondral ossification	IMP IMP: Inferred from mutant phenotype	9664685	MGI
involved in eye development	IGI IGI: Inferred from genetic interaction	16154126	MGI
involved in inflammatory response	IEP IEP: Inferred from expression pattern	12151307	MGI
acts upstream of or within intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	21703414	MGI
involved in intracellular iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	19252488	MGI
involved in kidney development	IGI IGI: Inferred from genetic interaction	16154126	MGI
acts upstream of or within male genitalia development	IGI IGI: Inferred from genetic interaction	9664685	MGI
involved in multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	19252488	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19252488	MGI
acts upstream of or within neuron differentiation	IMP IMP: Inferred from mutant phenotype	14623245	MGI
acts upstream of or within osteoblast differentiation	IGI IGI: Inferred from genetic interaction	16109715	MGI
involved in positive regulation of SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	19252488	MGI
involved in positive regulation of endothelial cell differentiation	IDA IDA: Inferred from direct assay	20406889	MGI
involved in positive regulation of endothelial cell proliferation	IDA IDA: Inferred from direct assay	20406889	MGI
involved in positive regulation of lipopolysaccharide-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	19252488	MGI
acts upstream of or within positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	9786991	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19252488	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bone morphogenetic protein 6

VG-1-related protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16712	LDN-214117	Inhibitor	99.92%	Unkown
HY-RS01541	BMP6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17946	Bmp6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24417	Bmp6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990974	Bezeotermin alfa		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bmp6	NCBI	NCBI:654

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