Bcl10 - B cell leukemia/lymphoma 10 Gene

Mus musculus

Also known as CLAP; ME10; cE10; CIPER; BCL-10; CARMEN

Gene ID: 12042 | Gene type: protein coding

About Bcl10

Summary

Enables CARD domain binding activity and identical protein binding activity. Involved in Antifungal innate immune response; neural tube closure; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; lymphocyte apoptotic process; and regulation of signal transduction. Located in cytosol; immunological synapse; and membrane raft. Part of CBM complex and polkadots. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; sensory organ; and vibrissa follicle. Human ortholog(s) of this gene implicated in MALT lymphoma; immunodeficiency 37; malignant mesothelioma; and non-Hodgkin lymphoma. Orthologous to human BCL10 (BCL10 immune signaling adaptor). [provided by Alliance of Genome Resources, Apr 2022]

Bcl10 Products(1)

mRNA	Protein	Name
NM_009740.2	NP_033870.1	B-cell lymphoma/leukemia 10

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables CARD domain binding	IPI IPI: Inferred from physical interaction	22265677	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	16831874	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10187771	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	35263589	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within B cell apoptotic process	IDA IDA: Inferred from direct assay	10753917	MGI
NOT acts upstream of or within B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11163238	MGI
acts upstream of or within T cell apoptotic process	IDA IDA: Inferred from direct assay	10753917	MGI
NOT acts upstream of or within T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	11163238	MGI
involved in antifungal innate immune response	IDA IDA: Inferred from direct assay	22265677	MGI
acts upstream of or within cellular defense response	IMP IMP: Inferred from mutant phenotype	11163238	MGI
NOT acts upstream of or within fibroblast apoptotic process	IMP IMP: Inferred from mutant phenotype	11163238	MGI
acts upstream of or within immunoglobulin mediated immune response	IMP IMP: Inferred from mutant phenotype	11163238	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	11163238	MGI
involved in non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	11163238	MGI
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	22265677	MGI
acts upstream of or within positive regulation of T cell activation	IMP IMP: Inferred from mutant phenotype	14614861	MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	10753917	MGI
involved in positive regulation of cytokine production	IDA IDA: Inferred from direct assay	22265677	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10753917	MGI
acts upstream of or within regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	14614861	MGI
acts upstream of or within response to fungus	IMP IMP: Inferred from mutant phenotype	16862125	MGI
involved in response to lipopolysaccharide	IDA IDA: Inferred from direct assay	35263589	MGI
NOT acts upstream of or within thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	11163238	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of CBM complex	IDA IDA: Inferred from direct assay	22265677	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12867038	MGI
located in cytosol	IDA IDA: Inferred from direct assay	16831874	MGI
located in immunological synapse	IDA IDA: Inferred from direct assay	14724296	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	12867038	MGI
part of polkadots	IDA IDA: Inferred from direct assay	16495340	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

B-cell lymphoma/leukemia 10

B-cell CLL/lymphoma 10	CARD-containing molecule enhancing NF-kappa-B
CARD-like apoptotic protein	CED-3/ICH-1 prodomain homologous E10-like regulator
cellular homolog of vCARMEN	cellular-E10
mammalian CARD-containing adapter molecule E10

Bcl10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Bcl10	Q9Z0H7	E10	Equine herpesvirus 2	Q66677	Confocal	11238466
Cross	Bcl10	Q9Z0H7	E10	Equine herpesvirus 2	Q66677	Anti Tag CoIP	11238466

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131902	MLT-231	Inhibitor	99.55%	Unkown
HY-142648A	(R)-MLT-985	Inhibitor	/	Unkown
HY-174371	INNO-220		/	Unkown
HY-RS01412	BCL10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17823	Bcl10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24291	Bcl10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcl10	NCBI	NCBI:8915

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