2. Gene
  3. Pcdh15 - protocadherin 15 Gene

Pcdh15 - protocadherin 15 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as av; roda; Ush1f; nmf19; Gm9815

Gene ID: 11994 | Gene type: protein coding

About Pcdh15

Summary

Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including adult walking behavior; detection of mechanical stimulus involved in sensory perception; and plasma membrane bounded cell projection organization. Located in several cellular components, including photoreceptor outer segment; plasma membrane; and stereocilium. Is expressed in several structures, including central nervous system; gut epithelium; metanephros; sensory organ; and vibrissa follicle. Used to study Usher syndrome type 1F and autosomal recessive nonsyndromic deafness 23. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Orthologous to human PCDH15 (protocadherin related 15). [provided by Alliance of Genome Resources, Apr 2022]

Pcdh15 Products(14)

mRNA Protein Name
NM_001142735.1 NP_001136207.1 protocadherin-15 isoform CD1-2 precursor
NM_001142736.1 NP_001136208.1 protocadherin-15 isoform CD1-4 precursor
NM_001142737.1 NP_001136209.1 protocadherin-15 isoform CD1-6 precursor
NM_001142738.1 NP_001136210.1 protocadherin-15 isoform CD1-8 precursor
NM_001142739.1 NP_001136211.1 protocadherin-15 isoform CD1-9 precursor
NM_001142740.1 NP_001136212.1 protocadherin-15 isoform CD1-7 precursor
NM_001142741.1 NP_001136213.1 protocadherin-15 isoform CD1-10 precursor
NM_001142742.1 NP_001136214.1 protocadherin-15 isoform CD2-1 precursor
NM_001142743.1 NP_001136215.1 protocadherin-15 isoform CD2-2 precursor
NM_001142746.1 NP_001136218.1 protocadherin-15 isoform CD3-1 precursor
NM_001142747.1 NP_001136219.1 protocadherin-15 isoform SI-1 precursor
NM_001142748.1 NP_001136220.1 protocadherin-15 isoform SI-2 precursor
NM_001142760.1 NP_001136232.1 protocadherin-15 isoform CD3-2 precursor
NM_023115.3 NP_075604.2 protocadherin-15 isoform CD1-1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15590703 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin filament organization IMP
IMP: Inferred from mutant phenotype
11124469 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
11124469 MGI
acts upstream of or within auditory receptor cell stereocilium organization IGI
IGI: Inferred from genetic interaction
15537665 MGI
acts upstream of or within auditory receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
10978835 MGI
acts upstream of or within detection of mechanical stimulus involved in equilibrioception IMP
IMP: Inferred from mutant phenotype
16481439 MGI
acts upstream of or within detection of mechanical stimulus involved in sensory perception of sound IMP
IMP: Inferred from mutant phenotype
16481439 MGI
acts upstream of or within inner ear auditory receptor cell differentiation IMP
IMP: Inferred from mutant phenotype
16481439 MGI
acts upstream of or within inner ear development IMP
IMP: Inferred from mutant phenotype
10978835 MGI
acts upstream of or within inner ear receptor cell stereocilium organization IMP
IMP: Inferred from mutant phenotype
18339676 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
10430593 MGI
acts upstream of or within morphogenesis of an epithelium IMP
IMP: Inferred from mutant phenotype
11138007 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
10978835 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
16481439 MGI
acts upstream of or within righting reflex IMP
IMP: Inferred from mutant phenotype
10978835 MGI
acts upstream of or within sensory perception of sound IGI
IGI: Inferred from genetic interaction
15537665 MGI
acts upstream of or within sensory perception of sound IMP
IMP: Inferred from mutant phenotype
5093631 MGI
acts upstream of or within startle response IMP
IMP: Inferred from mutant phenotype
15811708 MGI
acts upstream of or within visual perception IMP
IMP: Inferred from mutant phenotype
16799054 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16481439 MGI
located in photoreceptor outer segment IDA
IDA: Inferred from direct assay
14570705 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
23217710 MGI
is active in stereocilium EXP
EXP: Inferred from Experiment
26754646 MGI
located in stereocilium IDA
IDA: Inferred from direct assay
14570705 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protocadherin-15

Ames waltzer

protocadherin 15 CD2

Pcdh15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Pcdh15 Q99PJ1 Ush1c Mus musculus Q9ES64
Y2H
15590703
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10125 PCDH15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcdh15 NCBI NCBI:65217