2. Gene
  3. Atp2a2 - ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Gene

Atp2a2 - ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as SERCA2; SERCA2B; Serca2a; D5Wsu150e; mKIAA4195; 9530097L16Rik

Gene ID: 11938 | Gene type: protein coding

About Atp2a2

Summary

Enables several functions, including P-type calcium transporter activity; calcium ion binding activity; and protein C-terminus binding activity. Acts upstream of or within several processes, including T-tubule organization; cardiac muscle hypertrophy in response to stress; and regulation of heart contraction. Located in endoplasmic reticulum membrane; ribbon synapse; and sarcoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Used to study keratosis follicularis. Human ortholog(s) of this gene implicated in acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to human ATP2A2 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp2a2 Products(2)

mRNA Protein Name
NM_001110140.3 NP_001103610.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform b
NM_009722.3 NP_033852.1 sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables P-type calcium transporter activity IDA
IDA: Inferred from direct assay
9887021 MGI
enables P-type calcium transporter activity IMP
IMP: Inferred from mutant phenotype
29475982 MGI
enables enzyme binding IPI
IPI: Inferred from physical interaction
21903937 MGI
enables lncRNA binding IPI
IPI: Inferred from physical interaction
29475982 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14749390 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within ER-nucleus signaling pathway IMP
IMP: Inferred from mutant phenotype
14561754 MGI
acts upstream of or within T-tubule organization IMP
IMP: Inferred from mutant phenotype
22355118 MGI
involved in calcium ion import into sarcoplasmic reticulum IMP
IMP: Inferred from mutant phenotype
29475982 MGI
involved in calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
31819041 MGI
acts upstream of or within cardiac muscle hypertrophy in response to stress IDA
IDA: Inferred from direct assay
24137001 MGI
acts upstream of or within cellular response to oxidative stress IGI
IGI: Inferred from genetic interaction
25452428 MGI
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
9887021 MGI
acts upstream of or within intracellular calcium ion homeostasis IGI
IGI: Inferred from genetic interaction
12756243 MGI
acts upstream of or within intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
12756243 MGI
acts upstream of or within negative regulation of heart contraction IGI
IGI: Inferred from genetic interaction
10555147 MGI
acts upstream of or within neuron cellular homeostasis IGI
IGI: Inferred from genetic interaction
12756243 MGI
acts upstream of or within neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
12756243 MGI
acts upstream of or within organelle organization IMP
IMP: Inferred from mutant phenotype
22355118 MGI
acts upstream of or within positive regulation of cardiac muscle cell apoptotic process IDA
IDA: Inferred from direct assay
31819041 MGI
acts upstream of or within positive regulation of endoplasmic reticulum calcium ion concentration IMP
IMP: Inferred from mutant phenotype
30188326 MGI
acts upstream of or within regulation of calcium ion-dependent exocytosis of neurotransmitter IMP
IMP: Inferred from mutant phenotype
21106823 MGI
acts upstream of or within regulation of the force of heart contraction IGI
IGI: Inferred from genetic interaction
10555147 MGI
acts upstream of or within sarcoplasmic reticulum calcium ion transport IMP
IMP: Inferred from mutant phenotype
22355118 MGI
acts upstream of or within transition between fast and slow fiber IDA
IDA: Inferred from direct assay
18978355 MGI
Cellular Component GO Annotation Evidence Reference Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23395171 MGI
located in membrane IDA
IDA: Inferred from direct assay
16407245 MGI
located in ribbon synapse IDA
IDA: Inferred from direct assay
19932743 MGI
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
9038922 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sarcoplasmic/endoplasmic reticulum calcium ATPase 2

SR Ca(2+)-ATPase 2

calcium pump 2

endoplasmic reticulum class 1/2 Ca(2+) ATPase

sarco/endoplasmic reticulum Ca2+-ATPase 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131760 2'-NH2-ATP / Unkown
HY-RS01192 ATP2A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01195 ATP2B2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01199 ATP2C2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17846 Atp2a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24314 Atp2a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Atp2a2 NCBI NCBI:488