Kif1b - kinesin family member 1B Gene

Rattus norvegicus

Gene ID: 117548 | Gene type: protein coding

About Kif1b

Summary

Enables several functions, including ATP hydrolysis activity; microtubule motor activity; and scaffold protein binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; dense core granule cytoskeletal transport; and response to rotenone. Located in several cellular components, including cytoplasmic vesicle; mitochondrion; and neuron projection. Biomarker of amyotrophic lateral sclerosis and synucleinopathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2A1; carcinoma (multiple); multiple sclerosis; neuroblastoma; and pheochromocytoma. Orthologous to human KIF1B (Kinesin family member 1B). [provided by Alliance of Genome Resources, Apr 2022]

Kif1b Products(1)

mRNA	Protein	Name
NM_057200.2	NP_476548.1	kinesin-like protein KIF1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	19744141	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	12097473	RGD
enables microtubule motor activity	IDA IDA: Inferred from direct assay	19744141	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12204119	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	12097473	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in anterograde neuronal dense core vesicle transport	IGI IGI: Inferred from genetic interaction	28426968	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	24469107	RGD
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	15086790	RGD
involved in organelle transport along microtubule	IMP IMP: Inferred from mutant phenotype	15086790	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24469107	RGD
involved in protein localization to cell periphery	IMP IMP: Inferred from mutant phenotype	15086790	RGD
involved in response to rotenone	IEP IEP: Inferred from expression pattern	23263842	RGD
involved in retrograde neuronal dense core vesicle transport	IGI IGI: Inferred from genetic interaction	28426968	RGD
involved in transport along microtubule	IDA IDA: Inferred from direct assay	19744141	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	12204119	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	17571083	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	12204119	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kinesin-like protein KIF1B

kinesin-family protein KIF1Bbeta3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07270	KIF1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21616	Kif1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28134	Kif1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kif1b	NCBI	NCBI:23095

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