Slc25a4 - solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4 Gene

Mus musculus

Also known as Ant1; mANC1

Gene ID: 11739 | Gene type: protein coding

About Slc25a4

Summary

Enables ATP:ADP antiporter activity; Oxidative Phosphorylation uncoupler activity; and proton transmembrane transporter activity. Involved in several processes, including adenine nucleotide transport; positive regulation of mitophagy; and regulation of mitochondrial membrane permeability. Acts upstream of or within apoptotic mitochondrial changes. Located in mitochondrial inner membrane and myelin sheath. Part of mitochondrial permeability transition pore complex. Is expressed in embryo and liver. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to human SLC25A4 (solute carrier family 25 member 4). [provided by Alliance of Genome Resources, Apr 2022]

Slc25a4 Products(1)

mRNA	Protein	Name
NM_007450.5	NP_031476.3	ADP/ATP translocase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP:ADP antiporter activity	IDA IDA: Inferred from direct assay	31341297	MGI
enables ATP:ADP antiporter activity	IMP IMP: Inferred from mutant phenotype	31618756	MGI
enables oxidative phosphorylation uncoupler activity	IDA IDA: Inferred from direct assay	31341297	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11809823	MGI
enables proton transmembrane transporter activity	IDA IDA: Inferred from direct assay	31341297	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in adaptive thermogenesis	IMP IMP: Inferred from mutant phenotype	31341297	MGI
acts upstream of or within apoptotic mitochondrial changes	IGI IGI: Inferred from genetic interaction	18350175	MGI
involved in mitochondrial ADP transmembrane transport	IDA IDA: Inferred from direct assay	31341297	MGI
involved in mitochondrial ADP transmembrane transport	IMP IMP: Inferred from mutant phenotype	31618756	MGI
involved in mitochondrial ATP transmembrane transport	IDA IDA: Inferred from direct assay	31341297	MGI
involved in mitochondrial ATP transmembrane transport	IMP IMP: Inferred from mutant phenotype	31618756	MGI
involved in positive regulation of mitophagy	IDA IDA: Inferred from direct assay	31618756	MGI
involved in regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	31489369	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of mitochondrial permeability transition pore complex	IMP IMP: Inferred from mutant phenotype	31489369	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ADP/ATP translocase 1

ADP,ATP carrier protein 1	ADP,ATP carrier protein, heart/skeletal muscle
ANT 1	adenine nucleotide translocase-1
adenine nucleotide translocator 1, skeletal muscle	solute carrier family 25 member 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13122	SLC25A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22037	Slc25a4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc25a4	NCBI	NCBI:291

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