Cflar - CASP8 and FADD-like apoptosis regulator Gene

Rattus norvegicus

Also known as Flip

Gene ID: 117279 | Gene type: protein coding

About Cflar

Summary

Enables death receptor binding activity and protease binding activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and positive regulation of cell population proliferation. Located in membrane raft. Part of CD95 death-inducing signaling complex. Orthologous to human CFLAR (CASP8 and FADD like Apoptosis regulator). [provided by Alliance of Genome Resources, Apr 2022]

Cflar Products(2)

mRNA	Protein	Name
NM_001033864.4	NP_001029036.1	CASP8 and FADD-like apoptosis regulator isoform 1
NM_057138.3	NP_476479.1	CASP8 and FADD-like apoptosis regulator isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables death receptor binding	IPI IPI: Inferred from physical interaction	17518537	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	17518537	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17518537	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	16167066	RGD
involved in cellular response to epidermal growth factor stimulus	IEP IEP: Inferred from expression pattern	16033771	RGD
involved in cellular response to estradiol stimulus	IEP IEP: Inferred from expression pattern	26566102	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	12031707	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	18292530	RGD
involved in cellular response to nitric oxide	IMP IMP: Inferred from mutant phenotype	18292530	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12135878	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	14596792	RGD
involved in negative regulation of cellular response to transforming growth factor beta stimulus	IMP IMP: Inferred from mutant phenotype	18314484	RGD
involved in negative regulation of epithelial cell apoptotic process	IDA IDA: Inferred from direct assay	18314484	RGD
involved in negative regulation of hepatocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	16167066	RGD
involved in negative regulation of reactive oxygen species biosynthetic process	IMP IMP: Inferred from mutant phenotype	18292530	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23412386	RGD
involved in positive regulation of extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	24691542	RGD
involved in positive regulation of glomerular mesangial cell proliferation	IMP IMP: Inferred from mutant phenotype	24691542	RGD
involved in positive regulation of hepatocyte proliferation	IMP IMP: Inferred from mutant phenotype	16033771	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	20427667	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	23926673	RGD
involved in response to testosterone	IDA IDA: Inferred from direct assay	12811833	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of CD95 death-inducing signaling complex	IDA IDA: Inferred from direct assay	16493077	RGD
part of death-inducing signaling complex	IDA IDA: Inferred from direct assay	17518537	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CASP8 and FADD-like apoptosis regulator

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02570	CFLAR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21525	Cflar Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28043	Cflar Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cflar	NCBI	NCBI:8837

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