Acsl6 - acyl-CoA synthetase long-chain family member 6 Gene

Rattus norvegicus

Also known as Facl6; Lacsl

Gene ID: 117243 | Gene type: protein coding

About Acsl6

Summary

Enables arachidonate-CoA Ligase activity and protein homodimerization activity. Involved in several processes, including organophosphate biosynthetic process; positive regulation of long-chain fatty acid import across plasma membrane; and triglyceride biosynthetic process. Located in nucleus. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Apr 2022]

Acsl6 Products(1)

mRNA	Protein	Name
NM_130739.2	NP_570095.2	long-chain-fatty-acid--CoA ligase 6

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables arachidonate-CoA ligase activity	IDA IDA: Inferred from direct assay	28209804	RGD
enables long-chain fatty acid-CoA ligase activity	IDA IDA: Inferred from direct assay	1569043	RGD
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	20429931	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	16428347	RGD
involved in fatty acid transport	IGI IGI: Inferred from genetic interaction	16466685	RGD
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	1569043	RGD
involved in long-chain fatty-acyl-CoA biosynthetic process	IGI IGI: Inferred from genetic interaction	16466685	RGD
involved in neuron development	IEP IEP: Inferred from expression pattern	16848632	RGD
involved in phospholipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	15655248	RGD
involved in positive regulation of long-chain fatty acid import across plasma membrane	IMP IMP: Inferred from mutant phenotype	15655248	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	15051725	RGD
involved in response to gravity	IEP IEP: Inferred from expression pattern	16848632	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15942958	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	16772660	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	11118002	RGD
involved in triglyceride biosynthetic process	IGI IGI: Inferred from genetic interaction	16466685	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

long-chain-fatty-acid--CoA ligase 6

LACS 6	arachidonate--CoA ligase
fatty acid Coenzyme A ligase, long chain 6	long-chain acyl-CoA synthetase 6
long-chain-fatty-acid--CoA ligase, brain isozyme

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00204	ACSL6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20850	Acsl6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27364	Acsl6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Acsl6	NCBI	NCBI:23305

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