2. Gene
  3. Cplx2 - complexin 2 Gene

Cplx2 - complexin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 116657 | Gene type: protein coding

About Cplx2

Summary

Enables calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in synaptic vesicle exocytosis. Located in dendrite; neuronal cell body; and synapse. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in postsynapse and presynapse. Orthologous to human CPLX2 (complexin 2). [provided by Alliance of Genome Resources, Apr 2022]

Cplx2 Products(1)

mRNA Protein Name
NM_053878.2 NP_446330.1 complexin-2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SNARE binding IDA
IDA: Inferred from direct assay
11751907 RGD
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
19132534 RGD
enables syntaxin-1 binding IDA
IDA: Inferred from direct assay
7553862 RGD
Biological Process GO Annotation Evidence Reference Source
involved in synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
11751907 RGD
Cellular Component GO Annotation Evidence Reference Source
part of SNARE complex IDA
IDA: Inferred from direct assay
11751907 RGD
located in dendrite IDA
IDA: Inferred from direct assay
7553862 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
7553862 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
10430466 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
10430466 RGD
located in synapse IDA
IDA: Inferred from direct assay
7553862 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IDA
IDA: Inferred from direct assay
19132534 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complexin-2

CPX II

complexin II

synaphin-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03098 CPLX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19182 Cplx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25670 Cplx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cplx2 NCBI NCBI:10814