Aire - autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) Gene

Mus musculus

Gene ID: 11634 | Gene type: protein coding

About Aire

Summary

Enables identical protein binding activity. Involved in immune system development; positive regulation of chemokine production; and regulation of thymocyte migration. Acts upstream of or within humoral immune response; negative thymic T cell selection; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nuclear body. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study Guillain-Barre syndrome; Sjogren's syndrome; and autoimmune polyendocrine syndrome type 1. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator). [provided by Alliance of Genome Resources, Apr 2022]

Aire Products(12)

mRNA	Protein	Name
NM_001271549.1	NP_001258478.1	autoimmune regulator isoform 2
NM_001271550.1	NP_001258479.1	autoimmune regulator isoform 3
NM_001271551.1	NP_001258480.1	autoimmune regulator isoform 4
NM_001271552.1	NP_001258481.1	autoimmune regulator isoform 5
NM_001271553.1	NP_001258482.1	autoimmune regulator isoform 6
NM_001271554.1	NP_001258483.1	autoimmune regulator isoform 7
NM_001271555.1	NP_001258484.1	autoimmune regulator isoform 8
NM_001271556.1	NP_001258485.1	autoimmune regulator isoform 9
NM_001271557.1	NP_001258486.1	autoimmune regulator isoform 10
NM_001271558.1	NP_001258487.1	autoimmune regulator isoform 11
NM_001271559.1	NP_001258488.1	autoimmune regulator isoform 12
NM_009646.2	NP_033776.1	autoimmune regulator isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	11533054	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within humoral immune response	IMP IMP: Inferred from mutant phenotype	11854172	MGI
acts upstream of or within negative thymic T cell selection	IGI IGI: Inferred from genetic interaction	23382543	MGI
involved in peripheral T cell tolerance induction	IDA IDA: Inferred from direct assay	23993652	MGI
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	19923453	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17599412	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17599412	MGI
involved in regulation of thymocyte migration	IMP IMP: Inferred from mutant phenotype	19923453	MGI
involved in thymus epithelium morphogenesis	IMP IMP: Inferred from mutant phenotype	19015306	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	17599412	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11156688	MGI
located in female germ cell nucleus	IDA IDA: Inferred from direct assay	11156688	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	17599412	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	11156688	MGI
located in nuclear body	IDA IDA: Inferred from direct assay	19015306	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11156688	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

autoimmune regulator

APECED protein homolog	autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein homolog
autoimmune regulator AIRE1a

Aire Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Aire	Q9Z0E3	H2BC17	Homo sapiens	P23527	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	Cand1	Mus musculus	Q6ZQ38	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	Gemin5	Mus musculus	Q8BX17	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	Eftud2	Mus musculus	O08810	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	Gcn1	Mus musculus	Q3UHQ5	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	DDX5	Homo sapiens	P17844	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	H2bc18	Mus musculus	Q64525	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	H2AC6	Homo sapiens	Q93077	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	C1qbp	Mus musculus	O35658	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	Ddx17	Mus musculus	Q501J6	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	C1QBP	Homo sapiens	Q07021	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	Chd6	Mus musculus	A3KFM7	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	DDX17	Homo sapiens	Q92841	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	H2ac4	Mus musculus	C0HKE1	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	GEMIN5	Homo sapiens	Q8TEQ6	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	Ddx5	Mus musculus	Q61656	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	CHD6	Homo sapiens	Q8TD26	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	CAND1	Homo sapiens	Q86VP6	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	Aire	Mus musculus	Q9Z0E3	GMS	11533054
Intra	Aire	Q9Z0E3	EFTUD2	Homo sapiens	Q15029	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	Aire	Mus musculus	Q9Z0E3	Biochemical	11533054
Intra	Aire	Q9Z0E3	GCN1	Homo sapiens	Q92616	Anti Tag CoIP	20085707
Intra	Aire	Q9Z0E3	H3-4	Homo sapiens	Q16695	Anti Tag CoIP	20085707

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00501	AIRE Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17445	Aire Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23901	Aire Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aire	NCBI	NCBI:326
Rattus norvegicus	Aire	NCBI	NCBI:294328
Macaca mulatta	Aire	NCBI	NCBI:712858

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