Npnt - nephronectin Gene

Mus musculus

Also known as Nctn; POEM; 1110009H02Rik

Gene ID: 114249 | Gene type: protein coding

About Npnt

Summary

Enables Integrin binding activity. Involved in several processes, including cell-cell adhesion mediated by integrin; pilomotor reflex; and positive regulation of Alkaline Phosphatase activity. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; positive regulation of cell-substrate adhesion; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in basement membrane; extracellular region; and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human NPNT (nephronectin). [provided by Alliance of Genome Resources, Apr 2022]

Npnt Products(5)

mRNA	Protein	Name
NM_001029836.2	NP_001025007.1	nephronectin isoform b precursor
NM_001287101.1	NP_001274030.1	nephronectin isoform c precursor
NM_001287102.1	NP_001274031.1	nephronectin isoform d precursor
NM_001287103.1	NP_001274032.1	nephronectin isoform e
NM_033525.3	NP_277060.2	nephronectin isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables integrin binding	IDA IDA: Inferred from direct assay	19342381	MGI
enables integrin binding	IPI IPI: Inferred from physical interaction	11546798	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17537792	MGI
involved in cell-cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	19342381	MGI
acts upstream of or within cell-matrix adhesion	IDA IDA: Inferred from direct assay	11470831	MGI
acts upstream of or within cell-matrix adhesion	IPI IPI: Inferred from physical interaction	11470831	MGI
involved in cellular response to tumor necrosis factor	IDA IDA: Inferred from direct assay	21689636	MGI
involved in establishment of protein localization	IMP IMP: Inferred from mutant phenotype	21335239	MGI
acts upstream of or within extracellular matrix organization	IDA IDA: Inferred from direct assay	18757743	MGI
involved in pilomotor reflex	IMP IMP: Inferred from mutant phenotype	21335239	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19944102	MGI
involved in positive regulation of alkaline phosphatase activity	IDA IDA: Inferred from direct assay	19944102	MGI
acts upstream of or within positive regulation of cell-substrate adhesion	IDA IDA: Inferred from direct assay	18757743	MGI
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19944102	MGI
involved in positive regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	21335239	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21335239	MGI
acts upstream of or within positive regulation of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17537792	MGI
involved in smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	21335239	MGI
acts upstream of transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17537792	MGI
acts upstream of or within ureteric bud development	IMP IMP: Inferred from mutant phenotype	17537792	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	18757743	MGI
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	21335239	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	11470831	MGI
located in extracellular matrix	IPI IPI: Inferred from physical interaction	11470831	MGI
located in extracellular region	IDA IDA: Inferred from direct assay	19944102	MGI
located in smooth muscle contractile fiber	IDA IDA: Inferred from direct assay	21335239	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nephronectin

preosteoblast EGF-like repeat protein with MAM domain

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09493	NPNT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20785	Npnt Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27299	Npnt Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Npnt	NCBI	NCBI:255743

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