Dnm1l - dynamin 1-like Gene

Rattus norvegicus

Also known as DLP1; Drp1; Dnml1

Gene ID: 114114 | Gene type: protein coding

About Dnm1l

Summary

Enables BH2 domain binding activity; clathrin binding activity; and identical protein binding activity. Involved in several processes, including mitochondrion organization; positive regulation of cellular component organization; and synaptic vesicle recycling. Located in several cellular components, including Golgi membrane; perinuclear region of cytoplasm; and peroxisome. Is active in presynaptic endocytic zone membrane and synaptic vesicle membrane. Colocalizes with clathrin-coated pit and mitochondrial membrane. Biomarker of chronic kidney disease; dental fluorosis; pulmonary fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in encephalopathy due to defective mitochondrial and peroxisomal fission 1 and optic atrophy 5. Orthologous to human DNM1L (Dynamin 1 like). [provided by Alliance of Genome Resources, Apr 2022]

Dnm1l Products(1)

mRNA	Protein	Name
NM_053655.3	NP_446107.2	dynamin-1-like protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BH2 domain binding	IPI IPI: Inferred from physical interaction	23792689	RGD
enables clathrin binding	IPI IPI: Inferred from physical interaction	23792689	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	23658809	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18250306	RGD
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	20802490	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	23792689	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	23658809	RGD
involved in cellular response to lipid	IEP IEP: Inferred from expression pattern	18006463	RGD
involved in intracellular distribution of mitochondria	IMP IMP: Inferred from mutant phenotype	19605646	RGD
involved in mitochondrial fragmentation involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	17443673	RGD
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	19605646	RGD
involved in negative regulation of mitochondrial fusion	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	19605646	RGD
involved in positive regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	17443673	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in positive regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	17443673	RGD
involved in response to flavonoid	IEP IEP: Inferred from expression pattern	24637344	RGD
involved in response to hypobaric hypoxia	IEP IEP: Inferred from expression pattern	24637344	RGD
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	23792689	RGD
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	23792689	RGD
involved in synaptic vesicle recycling via endosome	IMP IMP: Inferred from mutant phenotype	23792689	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	9472031	RGD
NOT part of clathrin coat of trans-Golgi network vesicle	IDA IDA: Inferred from direct assay	9472031	RGD
located in clathrin-coated pit	IDA IDA: Inferred from direct assay	23792689	RGD
located in cytosol	IDA IDA: Inferred from direct assay	9472031	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	9472031	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	23792689	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	9472031	RGD
located in peroxisome	IDA IDA: Inferred from direct assay	12499366	RGD
NOT located in plasma membrane	IDA IDA: Inferred from direct assay	9472031	RGD
is active in presynaptic endocytic zone membrane	IDA IDA: Inferred from direct assay	23792689	RGD
located in secretory vesicle	IDA IDA: Inferred from direct assay	9472031	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	23792689	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dynamin-1-like protein

C-terminal region	N-terminal region
dynamin-like protein 1	dynamin-related protein 1

Dnm1l Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Dnm1l	O35303	Bcl2l1	Rattus norvegicus	P53563-1	Anti Bait CoIP	23792689

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-N0484	Liensinine		99.97%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03904	DNM1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17698	Dnm1l Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24160	Dnm1l Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dnm1l	NCBI	NCBI:10059

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