2. Gene
  3. Bmp3 - bone morphogenetic protein 3 Gene

Bmp3 - bone morphogenetic protein 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 9530029I04Rik

Gene ID: 110075 | Gene type: protein coding

About Bmp3

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta Receptor availability to Other ligands. Homozygous knockout mice for this gene exhibit increased bone density and volume, while overexpression of this gene in a transgenic mouse causes bone defects resulting in spontaneous rib fractures. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. [provided by RefSeq, Jul 2016]

Bmp3 Products(2)

mRNA Protein Name
NM_001310677.2 NP_001297606.1 bone morphogenetic protein 3 isoform 1 precursor
NM_173404.5 NP_775580.1 bone morphogenetic protein 3 isoform 2 preproprotein
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
1468569 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bone morphogenetic protein 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01538 BMP3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20696 Bmp3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bmp3 NCBI NCBI:651