Abr - active BCR-related gene Gene

Mus musculus

Gene ID: 109934 | Gene type: protein coding

About Abr

Summary

Enables GTPase activator activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of cellular extravasation; and regulation of vascular permeability. Acts upstream of or within several processes, including neuromuscular process controlling balance; regulation of vesicle-mediated transport; and response to lipopolysaccharide. Located in cytosol; glutamatergic synapse; and plasma membrane. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including alimentary system; mesothelium; metanephros; nervous system; and sensory organ. Orthologous to human ABR (ABR activator of RhoGEF and GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Abr Products(6)

mRNA	Protein	Name
NM_001291186.2	NP_001278115.1	active breakpoint cluster region-related protein isoform 4
NM_001346670.2	NP_001333599.1	active breakpoint cluster region-related protein isoform 5
NM_001363379.2	NP_001350308.1	active breakpoint cluster region-related protein isoform 6
NM_198018.3	NP_932135.1	active breakpoint cluster region-related protein isoform 1
NM_198894.3	NP_942597.1	active breakpoint cluster region-related protein isoform 2
NM_198895.3	NP_942598.1	active breakpoint cluster region-related protein isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activator activity	IDA IDA: Inferred from direct assay	17116687	MGI
enables GTPase activator activity	IGI IGI: Inferred from genetic interaction	19703997	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of or within brain development	IGI IGI: Inferred from genetic interaction	11684658	MGI
acts upstream of cell migration	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of establishment of localization in cell	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of or within inner ear morphogenesis	IGI IGI: Inferred from genetic interaction	11921339	MGI
acts upstream of macrophage migration	IGI IGI: Inferred from genetic interaction	17116687	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	20962234	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	20962234	MGI
involved in negative regulation of blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	23152932	MGI
involved in negative regulation of cellular extravasation	IMP IMP: Inferred from mutant phenotype	23152932	MGI
acts upstream of or within negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	19703997	MGI
acts upstream of or within negative regulation of macrophage migration	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of or within negative regulation of neutrophil degranulation	IGI IGI: Inferred from genetic interaction	19703997	MGI
acts upstream of or within neuromuscular process controlling balance	IGI IGI: Inferred from genetic interaction	11921339	MGI
acts upstream of neutrophil degranulation	IGI IGI: Inferred from genetic interaction	19703997	MGI
acts upstream of phagocytosis	IGI IGI: Inferred from genetic interaction	17116687	MGI
acts upstream of or within positive regulation of phagocytosis	IGI IGI: Inferred from genetic interaction	17116687	MGI
involved in regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	23152932	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19703997	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	20962234	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	20962234	MGI
located in cytosol	IDA IDA: Inferred from direct assay	17116687	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20962234	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20962234	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17116687	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

active breakpoint cluster region-related protein

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13010	Laquinimod		99.46%	Yes

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10528	Tasquinimod	Modulator	99.94%	Phase 3
HY-13743	Roquinimex	Inhibitor	99.69%	Phase 3
HY-W062904	Laquinimod sodium	Inhibitor	/	Phase 3
HY-100442	Paquinimod	Inhibitor	99.90%	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141537	ABR-238901	Inhibitor	98.71%	Unkown
HY-10528S	Tasquinimod-d3	Modulator	99.34%	Unkown
HY-100442S1	Paquinimod-d5-1	Inhibitor	98.19%	Unkown
HY-13010S	Laquinimod-d5	Inhibitor	98.25%	Unkown
HY-RS00110	ABR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100442S	Paquinimod-d5	Inhibitor	/	Unkown
HY-RS17572	Abr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24032	Abr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99436	Anatumomab mafenatox	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abr	NCBI	NCBI:29
Macaca fascicularis	Abr	NCBI	NCBI:102126046

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