2. Gene
  3. Rap1a - RAS-related protein 1a Gene

Rap1a - RAS-related protein 1a Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Rap1; G-22K; Krev-1

Gene ID: 109905 | Gene type: protein coding

About Rap1a

Summary

Enables GTPase activity and small GTPase binding activity. Involved in positive regulation of vasculogenesis. Acts upstream of or within several processes, including negative regulation of synaptic vesicle exocytosis; positive regulation of ERK1 and ERK2 cascade; and positive regulation of neuron projection development. Located in several cellular components, including cell junction; neuron projection; and plasma membrane. Part of guanyl-nucleotide exchange factor complex. Is expressed in brain; early conceptus; hemolymphoid system gland; and oocyte. Orthologous to human RAP1A (RAP1A, member of Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rap1a Products(1)

mRNA Protein Name
NM_145541.5 NP_663516.1 ras-related protein Rap-1A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activity IDA
IDA: Inferred from direct assay
12473665 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14712229 MGI
enables small GTPase binding IPI
IPI: Inferred from physical interaction
15894621 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of synaptic vesicle exocytosis IGI
IGI: Inferred from genetic interaction
23616533 MGI
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IGI
IGI: Inferred from genetic interaction
23616533 MGI
acts upstream of or within positive regulation of neuron projection development IDA
IDA: Inferred from direct assay
22732430 MGI
involved in positive regulation of vasculogenesis IMP
IMP: Inferred from mutant phenotype
19635461 MGI
acts upstream of or within small GTPase-mediated signal transduction IDA
IDA: Inferred from direct assay
12473665 MGI
acts upstream of synaptic vesicle exocytosis IGI
IGI: Inferred from genetic interaction
23616533 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cell junction IDA
IDA: Inferred from direct assay
19635461 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
22732430 MGI
part of guanyl-nucleotide exchange factor complex IDA
IDA: Inferred from direct assay
15894621 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
22732430 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17403904 MGI
located in sperm midpiece IDA
IDA: Inferred from direct assay
30360518 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related protein Rap-1A

GTP-binding protein SMG-P21A

ras-related protein Krev-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15871 GGTI298 Trifluoroacetate Inducer 99.87% Unkown
HY-123242 FTI-2153 Inhibitor 99.11% Unkown
HY-12369 GGTI-2133 Inhibitor 98.50% Unkown
HY-115489A GGTI-286 TFA Inhibitor / Unkown
HY-123242A FTI-2153 TFA Inhibitor 99.11% Unkown
HY-115489 GGTI-286 Inhibitor / Unkown
HY-100876 GGTI298 Inducer / Unkown
HY-117935 GGTI-286 hydrochloride Inhibitor / Unkown
HY-RS16300 Rap1a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-120229 GGTI-2147 Inhibitor / Unkown
HY-12369A GGTI-2133 TFA Inhibitor / Unkown
HY-RS11652 RAP1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-120271 GGTI-297 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rap1a NCBI NCBI:5906