ACOT2 - acyl-CoA thioesterase 2 Gene

Homo sapiens

Also known as MTE1; PTE2; CTE1A; PTE2A; CTE-IA; ZAP128

Gene ID: 10965 | Gene type: protein coding

About ACOT2

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,567,620-73,575,658 (from NCBI)

This gene has 4 transcripts (splice variants), 436 orthologues and 4 paralogues. Broad expression in fat (RPKM 57.3), liver (RPKM 39.8) and 21 other tissues.

Summary

This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

ACOT2 Products(3)

mRNA	Protein	Name
NM_001364177.1	NP_001351106.1	acyl-coenzyme A thioesterase 2, mitochondrial isoform 2
NM_001364178.1	NP_001351107.1	acyl-coenzyme A thioesterase 2, mitochondrial isoform 3
NM_006821.6	NP_006812.3	acyl-coenzyme A thioesterase 2, mitochondrial isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fatty acyl-CoA hydrolase activity	IDA IDA: Inferred from direct assay	10944470	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25464930	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in acyl-CoA metabolic process	IDA IDA: Inferred from direct assay	10944470	GOA
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	16940157	GOA
involved in very long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	16940157	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	16940157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOT2 Protein Structure

Bile_Hydr_Trans

BAAT_C

0
100
200
300
400
483 a.a.

Protein Preferred Names

Protein Names

acyl-coenzyme A thioesterase 2, mitochondrial

acyl-coenzyme A thioester hydrolase 2a

ACOT2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ACOT2	P49753	NLGN3	Homo sapiens	Q9NZ94-2	Anti Tag CoIP	25464930

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00177	ACOT2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22372	Acot2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ACOT2	MGD	MGI:2159605
Rattus norvegicus	ACOT2	RGD	RGD:621055

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