Mthfd1 - methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Gene

Mus musculus

Also known as Dcs; Mthfd; E430024A07Rik

Gene ID: 108156 | Gene type: protein coding

About Mthfd1

Summary

This gene encodes a trifunctional cytoplasmic enzyme. The encoded protein functions as a methylenetetrahydrofolate dehydrogenase, a methenyltetrahydrofolate cyclohydrolase, and a formyltetrahydrofolate synthase. The encoded enzyme functions in de novo synthesis of purines and thymidylate and in regeneration of methionine from homocysteine. [provided by RefSeq, Oct 2009]

Mthfd1 Products(1)

mRNA	Protein	Name
NM_138745.2	NP_620084.2	C-1-tetrahydrofolate synthase, cytoplasmic

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables formate-tetrahydrofolate ligase activity	IMP IMP: Inferred from mutant phenotype	15611115	MGI
enables methylenetetrahydrofolate dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	23704330	MGI
enables methylenetetrahydrofolate dehydrogenase (NADP+) activity	IMP IMP: Inferred from mutant phenotype	15611115	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in 10-formyltetrahydrofolate biosynthetic process	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in heart development	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in methionine metabolic process	IMP IMP: Inferred from mutant phenotype	23190757	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in neutrophil homeostasis	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in purine nucleotide biosynthetic process	IMP IMP: Inferred from mutant phenotype	23704330	MGI
acts upstream of purine ribonucleotide biosynthetic process	IMP IMP: Inferred from mutant phenotype	15611115	MGI
involved in serine family amino acid metabolic process	IMP IMP: Inferred from mutant phenotype	23190757	MGI
involved in somite development	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in tetrahydrofolate interconversion	IMP IMP: Inferred from mutant phenotype	23704330	MGI
involved in transsulfuration	IMP IMP: Inferred from mutant phenotype	23190757	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

C-1-tetrahydrofolate synthase, cytoplasmic

C1-THF synthase

C1-tetrahydrofolate synthase

Related Agents

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130251	DS18561882		99.87%	Unkown
HY-101943	LY 345899		≥98.0%	Unkown
HY-155950	TH9619		99.33%	Unkown
HY-131943	DS44960156		99.36%	Unkown
HY-155219	TH9028	Inhibitor	/	Unkown
HY-172910	MTHFD2-IN-6	Inhibitor	/	Unkown
HY-RS08774	MTHFD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08775	MTHFD1L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17098	Mthfd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20214	Mthfd1l Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23542	Mthfd1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26720	Mthfd1l Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mthfd1	NCBI	NCBI:4522

Name
Email *

	Sorry, but the email address you supplied was invalid.