Adgrb1 - adhesion G protein-coupled receptor B1 Gene

Mus musculus

Also known as Bai1; mKIAA4089; B830018M07Rik

Gene ID: 107831 | Gene type: protein coding

About Adgrb1

Summary

Enables several functions, including PDZ domain binding activity; lipopolysaccharide binding activity; and phosphatidylserine binding activity. Involved in several processes, including negative regulation of protein metabolic process; phagocytosis; and positive regulation of myoblast fusion. Acts upstream of or within positive regulation of synapse assembly. Located in several cellular components, including focal adhesion; phagocytic cup; and postsynaptic density. Is expressed in several structures, including brain and reproductive system. Human ortholog(s) of this gene implicated in glioblastoma. Orthologous to human ADGRB1 (adhesion G protein-coupled receptor B1). [provided by Alliance of Genome Resources, Apr 2022]

Adgrb1 Products(2)

mRNA	Protein	Name
NM_001359759.1	NP_001346688.1	adhesion G protein-coupled receptor B1 isoform 2
NM_174991.3	NP_778156.2	adhesion G protein-coupled receptor B1 isoform 1precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	23782696	MGI
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	21245295	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	17960134	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11245925	MGI
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	17960134	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in defense response to Gram-negative bacterium	IMP IMP: Inferred from mutant phenotype	21245295	MGI
involved in engulfment of apoptotic cell	IDA IDA: Inferred from direct assay	17960134	MGI
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	25751059	MGI
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	25751059	MGI
involved in phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	26838550	MGI
involved in phagocytosis, recognition	IMP IMP: Inferred from mutant phenotype	21245295	MGI
involved in positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	23615608	MGI
acts upstream of or within positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	24613359	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	25751059	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	20888903	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	20888903	MGI
located in phagocytic cup	IDA IDA: Inferred from direct assay	17960134	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17960134	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	23595754	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

adhesion G protein-coupled receptor B1

brain-specific angiogenesis inhibitor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131031	KCC-07		99.95%	Unkown
HY-RS00345	ADGRB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19762	Adgrb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26259	Adgrb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adgrb1	NCBI	NCBI:575

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