Ovol2 - ovo like zinc finger 2 Gene

Mus musculus

Also known as MOVO; Ovo2; M-OVO; movo2; Zfp339; M-OVO-A; M-OVO-B; 1700108N11Rik; 1810007D21Rik

Gene ID: 107586 | Gene type: protein coding

About Ovol2

Summary

Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including negative regulation of epithelial to mesenchymal transition; regulation of SMAD protein signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including circulatory system development; embryonic morphogenesis; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; gut; head surface ectoderm; and otocyst. Human ortholog(s) of this gene implicated in posterior polymorphous corneal dystrophy 1. Orthologous to human OVOL2 (ovo like zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]

Ovol2 Products(2)

mRNA	Protein	Name
NM_026924.3	NP_081200.2	transcription factor Ovo-like 2 isoform A
NM_152947.2	NP_694455.2	transcription factor Ovo-like 2 isoform B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15225875	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	24735878	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	28455959	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	24735878	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	17573777	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16423343	MGI
acts upstream of or within dorsal/ventral pattern formation	IMP IMP: Inferred from mutant phenotype	16423343	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	16423343	MGI
acts upstream of or within endocardium formation	IMP IMP: Inferred from mutant phenotype	17573777	MGI
involved in epidermal cell differentiation	IMP IMP: Inferred from mutant phenotype	24735879	MGI
acts upstream of or within epidermis development	IGI IGI: Inferred from genetic interaction	24735878	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	16423343	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	17573777	MGI
acts upstream of or within heart trabecula formation	IMP IMP: Inferred from mutant phenotype	17573777	MGI
acts upstream of or within labyrinthine layer blood vessel development	IMP IMP: Inferred from mutant phenotype	17573777	MGI
involved in negative regulation of SMAD protein signal transduction	IDA IDA: Inferred from direct assay	28455959	MGI
acts upstream of or within negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	16423343	MGI
involved in negative regulation of epithelial to mesenchymal transition	IDA IDA: Inferred from direct assay	28455959	MGI
involved in negative regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	24735879	MGI
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	28455959	MGI
acts upstream of or within negative regulation of stem cell proliferation	IGI IGI: Inferred from genetic interaction	24735878	MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	28455959	MGI
acts upstream of or within neural crest cell migration	IMP IMP: Inferred from mutant phenotype	16423343	MGI
acts upstream of or within neural fold formation	IMP IMP: Inferred from mutant phenotype	16423343	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	28455959	MGI
acts upstream of or within positive regulation of keratinocyte differentiation	IDA IDA: Inferred from direct assay	24735878	MGI
involved in regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	19700410	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	9468311	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transcription factor Ovo-like 2

MOVO-B zinc finger protein	MOVO-C zinc finger protein
OVO homolog-like 2	ovo-like 2
zinc finger OVO2	zinc finger protein 339
zinc finger protein mOVO

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09884	OVOL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22705	Ovol2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ovol2	NCBI	NCBI:58495

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