Sharpin - SHANK-associated RH domain interacting protein Gene

Mus musculus

Also known as cpdm; SIPL1; RBCKL1; 0610041B22Rik

Gene ID: 106025 | Gene type: protein coding

About Sharpin

Summary

Predicted to enable several functions, including identical protein binding activity; ubiquitin binding activity; and ubiquitin-protein transferase activity. Involved in negative regulation of inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB signaling; and regulation of tumor necrosis factor-mediated signaling pathway. Acts upstream of or within apoptotic nuclear changes; keratinization; and mitochondrion organization. Predicted to be located in cytosol; dendrite; and postsynaptic density. Predicted to be part of LUBAC complex. Is expressed in genitourinary system. Used to study atopic dermatitis. Orthologous to human SHARPIN (SHANK associated RH domain interactor). [provided by Alliance of Genome Resources, Apr 2022]

Sharpin Products(1)

mRNA	Protein	Name
NM_025340.2	NP_079616.2	sharpin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20956555	MGI
enables protein-macromolecule adaptor activity	IMP IMP: Inferred from mutant phenotype	34755089	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic nuclear changes	IMP IMP: Inferred from mutant phenotype	7792947	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	7792947	MGI
acts upstream of or within keratinization	IMP IMP: Inferred from mutant phenotype	7792947	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	7792947	MGI
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	21455173	MGI
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	21455173	MGI
involved in regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	21455173	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of LUBAC complex	IDA IDA: Inferred from direct assay	34755089	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sharpin

mSIPL1	protein kinase C-interacting protein RBCC like 1
shank-associated RH domain-interacting protein	shank-interacting protein-like 1

Sharpin Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Sharpin	Q91WA6	Eya1	Mus musculus	P97767	Pull Down	20956555
Intra	Sharpin	Q91WA6	Rnf31	Mus musculus	Q924T7	Anti Bait CoIP	21455181
Intra	Sharpin	Q91WA6	Rnf31	Mus musculus	Q924T7	Anti Bait CoIP	21455180
Intra	Sharpin	Q91WA6	Rnf31	Mus musculus	Q924T7	Anti Bait CoIP	23942237
Intra	Sharpin	Q91WA6	Eya2	Mus musculus	O08575	Y2H	20956555
Intra	Sharpin	Q91WA6	Eya2	Mus musculus	O08575	Pull Down	20956555

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12853	SHARPIN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19284	Sharpin Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25774	Sharpin Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sharpin	NCBI	NCBI:81858

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