Mycbp2 - MYC binding protein 2, E3 ubiquitin protein ligase Gene

Mus musculus

Also known as Pam; Phr1; C130061D10Rik

Gene ID: 105689 | Gene type: protein coding

About Mycbp2

Summary

Enables identical protein binding activity. Involved in several processes, including central nervous system projection neuron axonogenesis; circadian regulation of gene expression; and positive regulation of protein ubiquitination. Acts upstream of or within several processes, including branchiomotor neuron axon guidance; negative regulation of protein catabolic process; and regulation of Cytoskeleton organization. Located in axon and microtubule Cytoskeleton. Is expressed in nervous system and neural retina. Orthologous to human MYCBP2 (MYC binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Mycbp2 Products(1)

mRNA	Protein	Name
NM_207215.2	NP_997098.2	E3 ubiquitin-protein ligase MYCBP2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12522145	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within branchiomotor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18031680	MGI
acts upstream of or within cell morphogenesis involved in neuron differentiation	IMP IMP: Inferred from mutant phenotype	18031680	MGI
acts upstream of or within central nervous system projection neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	18031680	MGI
involved in central nervous system projection neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	17901218	MGI
involved in circadian regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20534529	MGI
acts upstream of or within motor neuron axon guidance	IMP IMP: Inferred from mutant phenotype	18031680	MGI
acts upstream of or within negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	19398581	MGI
involved in neuromuscular process	IMP IMP: Inferred from mutant phenotype	17901218	MGI
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	20534529	MGI
involved in regulation of axon guidance	IMP IMP: Inferred from mutant phenotype	17901218	MGI
acts upstream of or within regulation of cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	18031680	MGI
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	18031680	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	18031680	MGI
located in microtubule cytoskeleton	IDA IDA: Inferred from direct assay	18031680	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase MYCBP2

Myc-binding protein 2	RING-type E3 ubiquitin transferase MYCBP2
pam, highwire, rpm 1	pam/highwire/rpm-1 protein
probable E3 ubiquitin-protein ligase MYCBP2	protein Magellan
protein associated with Myc

Mycbp2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Mycbp2	Q7TPH6	Slc12a5	Rattus norvegicus	Q63633	Pull Down	18769030

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08881	MYCBP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21160	Mycbp2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27676	Mycbp2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mycbp2	NCBI	NCBI:23077

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