Cbll1 - Casitas B-lineage lymphoma-like 1 Gene

Mus musculus

Also known as Hakai; c-Cbl-like

Gene ID: 104836 | Gene type: protein coding

About Cbll1

Summary

Enables identical protein binding activity and ubiquitin protein Ligase activity. Acts upstream of or within negative regulation of cell adhesion; positive regulation of cell migration; and positive regulation of endocytosis. Located in cytoplasm and nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in heart ventricle. Orthologous to human CBLL1 (Cbl proto-oncogene like 1). [provided by Alliance of Genome Resources, Apr 2022]

Cbll1 Products(3)

mRNA	Protein	Name
NM_001253847.1	NP_001240776.1	E3 ubiquitin-protein ligase Hakai isoform 1
NM_001253848.1	NP_001240777.1	E3 ubiquitin-protein ligase Hakai isoform 3
NM_134048.2	NP_598809.1	E3 ubiquitin-protein ligase Hakai isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	22252131	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11836526	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	11836526	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	11836526	MGI
acts upstream of or within positive regulation of cell migration	IDA IDA: Inferred from direct assay	11836526	MGI
acts upstream of or within positive regulation of endocytosis	IDA IDA: Inferred from direct assay	11836526	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA N6-methyladenosine methyltransferase complex	IDA IDA: Inferred from direct assay	29547716	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	29547716	MGI
located in nucleus	IDA IDA: Inferred from direct assay	29547716	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase Hakai

E-cadherin binding protein E7	RING-type E3 ubiquitin transferase Hakai
c-Cbl-like protein 1	casitas B-lineage lymphoma-transforming sequence-like protein 1

Cbll1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Cbll1	Q9JIY2	DOK1	Homo sapiens	Q99704	Competition Binding	22252131
Cross	Cbll1	Q9JIY2	DOK1	Homo sapiens	Q99704	Anti Tag CoIP	22252131
Cross	Cbll1	Q9JIY2	CTTN	Homo sapiens	Q14247	Anti Tag CoIP	22252131
Intra	Cbll1	Q9JIY2	Cttn	Mus musculus	Q60598	Anti Tag CoIP	22252131
Cross	Cbll1	Q9JIY2	CDH1	Homo sapiens	P12830	Pull Down	22252131
Cross	Cbll1	Q9JIY2	CDH1	Homo sapiens	P12830	NMR	22252131
Intra	Cbll1	Q9JIY2	CDH1	Homo sapiens	P12830	Anti Tag CoIP	22252131
Cross	Cbll1	Q9JIY2	CDH1	Homo sapiens	P12830	ITC	22252131
Intra	Cbll1	Q9JIY2	Cbll1	Mus musculus	Q9JIY2	X-Ray Diffraction	22252131
Intra	Cbll1	Q9JIY2	Cbll1	Mus musculus	Q9JIY2	GMS	22252131
Intra	Cbll1	Q9JIY2	Cbll1	Mus musculus	Q9JIY2	DLS	22252131
Intra	Cbll1	Q9JIY2	Cbll1	Mus musculus	Q9JIY2	Anti Tag CoIP	22252131

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02000	CBLL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20871	Cbll1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27388	Cbll1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cbll1	NCBI	NCBI:79872

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