UBAC1 - UBA domain containing 1 Gene

Homo sapiens

Also known as KPC2; GBDR1; UBADC1

Gene ID: 10422 | Gene type: protein coding

About UBAC1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,932,969-135,961,373 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 32.5), testis (RPKM 24.1) and 25 other tissues.

Summary

Predicted to be involved in protein ubiquitination. Located in Golgi apparatus; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

UBAC1 Products(1)

mRNA	Protein	Name
NM_016172.3	NP_057256.2	ubiquitin-associated domain-containing protein 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	16227581	GOA
enables proteasome binding	IDA IDA: Inferred from direct assay	16227581	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein maturation	IDA IDA: Inferred from direct assay	25860612	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16227581	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBAC1 Protein Structure

UBA

0
100
200
300
405 a.a.

Protein Preferred Names

Protein Names

ubiquitin-associated domain-containing protein 1

E3 ubiquitin-protein ligase subunit KPC2

UBAC1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBAC1	Q9BSL1	MCM10	Homo sapiens	Q7L590-2	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	MCM10	Homo sapiens	Q7L590-2	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	RNF123	Homo sapiens	Q5XPI4	Anti Bait CoIP	17353931
Intra	UBAC1	Q9BSL1	RNF123	Homo sapiens	Q5XPI4	Anti Tag CoIP	33961781
Intra	UBAC1	Q9BSL1	RNF123	Homo sapiens	Q5XPI4	Anti Tag CoIP	28514442
Intra	UBAC1	Q9BSL1	CCDC138	Homo sapiens	Q96M89-2	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	CCDC138	Homo sapiens	Q96M89-2	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	PLAAT2	Homo sapiens	Q9NWW9	Validated Y2H	32296183
Intra	UBAC1	Q9BSL1	PLAAT2	Homo sapiens	Q9NWW9	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	PLAAT2	Homo sapiens	Q9NWW9	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	MGAT3	Homo sapiens	Q09327	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	MGAT3	Homo sapiens	Q09327	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	PSEN2	Homo sapiens	P49810	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	PSEN2	Homo sapiens	P49810	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	PSEN2	Homo sapiens	P49810	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	ALS2	Homo sapiens	A0A0S2Z5Q7	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	ALS2	Homo sapiens	A0A0S2Z5Q7	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	ALS2	Homo sapiens	A0A0S2Z5Q7	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	SPART	Homo sapiens	Q8N0X7	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	SPART	Homo sapiens	Q8N0X7	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	UBC	Homo sapiens	P0CG48	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	UBC	Homo sapiens	P0CG48	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	UBB	Homo sapiens	P0CG47	Anti Tag CoIP	28514442
Intra	UBAC1	Q9BSL1	UBB	Homo sapiens	P0CG47	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	UBB	Homo sapiens	P0CG47	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	UBB	Homo sapiens	P0CG47	Anti Tag CoIP	33961781
Intra	UBAC1	Q9BSL1	UCHL1	Homo sapiens	P09936	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	UCHL1	Homo sapiens	P09936	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	UCHL1	Homo sapiens	P09936	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	RNF216	Homo sapiens	Q9NWF9	Validated Y2H	32296183
Intra	UBAC1	Q9BSL1	RNF216	Homo sapiens	Q9NWF9	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	RNF216	Homo sapiens	Q9NWF9	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	25416956
Intra	UBAC1	Q9BSL1	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	UBAC1	Q9BSL1	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	UBAC1	Q9BSL1	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Validated Y2H	25416956
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Y2H Array	25416956
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Y2H	21516116
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Y2H Prey Pooling	25416956
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	TRIM2	Homo sapiens	Q9C040	Validated Y2H	32296183
Intra	UBAC1	Q9BSL1	IGFBP6	Homo sapiens	P24592	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	IGFBP6	Homo sapiens	P24592	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	UBAC1	Q9BSL1	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	UBAC1	Q9BSL1	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBAC1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700392	UBAC1 Protein, Human (GST)	Q9BSL1 (M1-T405)	≥95%

Related Diseases

Diseases

Alias

Urinary Tract Infection

Urinary Tract Infections	Uti
Urinary Tract Infection Nos	Uti - [Urinary Tract Infection]
Uti Nos - [Urinary Tract Infection Nos]	Urosepsis Nos
E Coli Uti	E Coli Urinary Tract Infection
Escherichia Coli Uti

Pyelitis

Acute Pyelonephritis

Apn - [Acute Pyelonephritis]

Granulomatous Disease, Chronic, Autosomal Recessive, 3

CGD3	Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Iii
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 3	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Iii
Cgd, Autosomal Recessive Cytochrome B-Positive, Type Iii	Granulomatous Disease, Chronic, Due To Ncf4 Deficiency
Chronic Granulomatous Disease 3, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 3
Autosomal Recessive Cytochrome B-Positive Cgd Type Iii	Cdg3
Chronic Granulomatous Disease Due To Ncf4 Deficiency	Cgd Autosomal Recessive Cytochrome B-Positive Type Iii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Iii	Granulomatous Disease Chronic Due To Ncf4 Deficiency
Granulomatous Disease, Chronic, Autosomal Recessive Cytochrome B-Positive, Type 3

Blood Group, Globoside System

Globe Disease	GLOB
Blood Group System, Globoside

Parametritis

Pelvic Cellulitis

Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 9	CMS9
Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency	Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency

Endophthalmitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15326	UBAC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UBAC1	MGD	MGI:1920995
Macaca mulatta	UBAC1	VGNC	VGNC:79837
Canis familiaris	UBAC1	VGNC	VGNC:48042
Felis catus	UBAC1	VGNC	VGNC:66752
Rattus norvegicus	UBAC1	RGD	RGD:1359542
Bos taurus	UBAC1	VGNC	VGNC:36567
Others	UBAC1	NCBI

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