Nlrp6 - NLR family, pyrin domain containing 6 Gene

Mus musculus

Also known as Avr; Navr; Nalp6; Pypaf5; Non-AVR; Navr/Avr

Gene ID: 101613 | Gene type: protein coding

About Nlrp6

Summary

The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. [provided by RefSeq, Feb 2013]

Nlrp6 Products(1)

mRNA	Protein	Name
NM_133946.2	NP_598707.2	NACHT, LRR and PYD domains-containing protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	34678144	MGI
enables lipoteichoic acid binding	IDA IDA: Inferred from direct assay	30392956	MGI
enables molecular condensate scaffold activity	IDA IDA: Inferred from direct assay	34678144	MGI
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	34678144	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26494172	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in NLRP6 inflammasome complex assembly	IDA IDA: Inferred from direct assay	32424362	MGI
acts upstream of or within activation of cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	30248149	MGI
acts upstream of or within acute inflammatory response	IMP IMP: Inferred from mutant phenotype	30248149	MGI
acts upstream of or within acute inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	30248149	MGI
involved in antiviral innate immune response	IDA IDA: Inferred from direct assay	34678144	MGI
involved in antiviral innate immune response	IMP IMP: Inferred from mutant phenotype	26494172	MGI
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	30392956	MGI
involved in defense response to virus	IMP IMP: Inferred from mutant phenotype	26494172	MGI
NOT involved in host-mediated regulation of intestinal microbiota composition	IMP IMP: Inferred from mutant phenotype	28801232	MGI
involved in host-mediated regulation of intestinal microbiota composition	IMP IMP: Inferred from mutant phenotype	26638072	MGI
acts upstream of or within interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	30248149	MGI
acts upstream of or within interleukin-18 production	IMP IMP: Inferred from mutant phenotype	30248149	MGI
acts upstream of or within necroptotic process	IMP IMP: Inferred from mutant phenotype	30248149	MGI
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	22763455	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	22763455	MGI
acts upstream of or within negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	22763455	MGI
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	22763455	MGI
acts upstream of or within negative regulation of immune response	IMP IMP: Inferred from mutant phenotype	22763455	MGI
involved in negative regulation of inflammatory response to antigenic stimulus	IMP IMP: Inferred from mutant phenotype	22763455	MGI
acts upstream of or within negative regulation of toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22763455	MGI
acts upstream of or within negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	30248149	MGI
acts upstream of or within neutrophil-mediated killing of gram-positive bacterium	IMP IMP: Inferred from mutant phenotype	30248149	MGI
involved in positive regulation of inflammatory response	IDA IDA: Inferred from direct assay	26494172	MGI
involved in positive regulation of interleukin-18-mediated signaling pathway	IDA IDA: Inferred from direct assay	30392956	MGI
involved in positive regulation of interleukin-18-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	26638072	MGI
involved in protein homooligomerization	IDA IDA: Inferred from direct assay	34678144	MGI
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	34678144	MGI
acts upstream of or within pyroptotic inflammatory response	IMP IMP: Inferred from mutant phenotype	30248149	MGI
acts upstream of or within regulation of autophagy	IMP IMP: Inferred from mutant phenotype	24581500	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	23696660	MGI
involved in regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	21543645	MGI
acts upstream of or within regulation of mucus secretion	IMP IMP: Inferred from mutant phenotype	24581500	MGI
acts upstream of or within response to bacterium	IMP IMP: Inferred from mutant phenotype	23075849	MGI
acts upstream of or within wound healing	IMP IMP: Inferred from mutant phenotype	21593405	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NLRP6 inflammasome complex	IDA IDA: Inferred from direct assay	32424362	MGI
part of canonical inflammasome complex	IDA IDA: Inferred from direct assay	30248149	MGI
is active in non-membrane-bounded organelle	IDA IDA: Inferred from direct assay	34678144	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NACHT, LRR and PYD domains-containing protein 6

NACHT, leucine rich repeat and PYD containing 6	NACHT/LRR/pyrin domain-containing protein 6
PYRIN-containing APAF1-like protein 5	angiotensin II/vasopressin receptor
non-angiotensin-vasopressin receptor

Nlrp6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nlrp6	Q91WS2	Dhx15	Mus musculus	O35286	Anti Bait CoIP	26494172

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09362	NLRP6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17708	Nlrp6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24173	Nlrp6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nlrp6	NCBI	NCBI:171389

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