Adamts9 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9 Gene

Mus musculus

Also known as UND3; UND4; Gsfund3; Mhdaund3; Mhdaund4; 1810011L16Rik; 8430403M15Rik; E030027K14Rik

Gene ID: 101401 | Gene type: protein coding

About Adamts9

Summary

Enables endopeptidase activity. Involved in several processes, including circulatory system development; negative regulation of endothelial cell migration; and negative regulation of sprouting angiogenesis. Acts upstream of or within positive regulation of melanocyte differentiation; proteolysis; and response to bacterium. Located in cell surface and extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; embryo mesenchyme; eye; and genitourinary system. Orthologous to human ADAMTS9 (ADAM metallopeptidase with thrombospondin type 1 motif 9). [provided by Alliance of Genome Resources, Apr 2022]

Adamts9 Products(1)

mRNA	Protein	Name
NM_175314.4	NP_780523.3	A disintegrin and metalloproteinase with thrombospondin motifs 9 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables endopeptidase activity	IDA IDA: Inferred from direct assay	18454205	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	20096780	MGI
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	27687499	MGI
acts upstream of or within cornea development in camera-type eye	IMP IMP: Inferred from mutant phenotype	27687499	MGI
involved in endothelial cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	20093484	MGI
involved in extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	20096780	MGI
involved in heart valve morphogenesis	IMP IMP: Inferred from mutant phenotype	20096780	MGI
acts upstream of or within lens development in camera-type eye	IMP IMP: Inferred from mutant phenotype	27687499	MGI
acts upstream of melanocyte differentiation	IGI IGI: Inferred from genetic interaction	18454205	MGI
involved in negative regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	20093484	MGI
involved in negative regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	20093484	MGI
acts upstream of or within positive regulation of melanocyte differentiation	IGI IGI: Inferred from genetic interaction	18454205	MGI
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	18454205	MGI
acts upstream of or within regulation of developmental pigmentation	IGI IGI: Inferred from genetic interaction	18454205	MGI
acts upstream of or within response to bacterium	IEP IEP: Inferred from expression pattern	23012479	MGI
involved in ventricular cardiac muscle tissue development	IMP IMP: Inferred from mutant phenotype	20096780	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	24220035	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	18454205	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 9

a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00309	ADAMTS9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19831	Adamts9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26328	Adamts9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adamts9	NCBI	NCBI:56999

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