1. Gene
  2. SH2D3C - SH2 domain containing 3C Gene

SH2D3C - SH2 domain containing 3C Gene

Homo sapiens

Also known as CHAT; NSP3; SHEP1; PRO34088

Gene ID: 10044 | Gene type: protein coding

About SH2D3C

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:127,738,317-127,778,666 (from NCBI)

This gene has 13 transcripts (splice variants), 278 orthologues and 2 paralogues. Broad expression in spleen (RPKM 12.4), lung (RPKM 10.5) and 22 other tissues.

Summary

This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

SH2D3C Products(7)

mRNA Protein Name
NM_001142531.1 NP_001136003.1 SH2 domain-containing protein 3C isoform c
NM_001142532.1 NP_001136004.1 SH2 domain-containing protein 3C isoform c
NM_001142533.1 NP_001136005.1 SH2 domain-containing protein 3C isoform d
NM_001142534.1 NP_001136006.1 SH2 domain-containing protein 3C isoform e
NM_001252334.2 NP_001239263.1 SH2 domain-containing protein 3C isoform f
NM_005489.4 NP_005480.2 SH2 domain-containing protein 3C isoform b
NM_170600.3 NP_733745.1 SH2 domain-containing protein 3C isoform a

SH2D3C Protein Structure

SH2

SH2: SH2 domain (220 - 300)

RasGEF

RasGEF: RasGEF domain (586 - 713)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 860 a.a.
Protein Preferred Names Protein Names

SH2 domain-containing protein 3C

SH2 domain-containing Eph receptor-binding protein 1

Related Diseases

Diseases Alias
Eastern Equine Encephalitis

Eee

Neuroinvasive Eastern Equine Encephalitis Virus Infection

Eastern Equine Encephalomyelitis

Encephalomyelitis, Eastern Equine

Triple E

Eastern Equine Encephalitis Virus Infection

Neuroinvasive Eastern Equine Encephalitis Virus Disease

Eee - [Eastern Equine Encephalitis]

Western Equine Encephalitis

Western Equine Encephalomyelitis

Wee

Encephalomyelitis, Western Equine

Western Equine Encephalitis Virus Infection

Wee - [Western Equine Encephalitis]

Western Equine Encephalitis Virus

Blue Toe Syndrome
Noonan Syndrome 12

NS12

Venezuelan Equine Encephalitis

Venezuelan Equine Fever

Venezuelan Equine Encephalomyelitis

Encephalitis Venezuelan Equine

Encephalomyelitis, Venezuelan Equine

Venezuelan Encephalitis

Disorder Due To Venezuelan Equine Encephalitis Virus

Venezuelan Equine Encephalitis Virus Infection

Venezuelan Equine Encephalomyelitis Virus Disease

Ross River Fever

Ross River Virus Disease

Ross River Virus Infection

Noonan Syndrome 7

NS7

Noonan Syndrome, Type 7

Acute Diarrhea
Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]

Griscelli Syndrome, Type 3

Griscelli Syndrome Type 3

GS3

Griscelli-Prunieras Syndrome Type 3

Hypomelanosis With No Immunologic Or Neurologic Manifestations

Griscelli Syndrome 3

Coronavirus Infectious Disease
Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus SH2D3C MGD MGI:1351631
Macaca mulatta SH2D3C VGNC VGNC:77253
Rattus norvegicus SH2D3C RGD RGD:1307287
Bos taurus SH2D3C VGNC VGNC:34559
Canis familiaris SH2D3C VGNC VGNC:46113
Felis catus SH2D3C VGNC VGNC:65094