TOM1 - target of myb1 membrane trafficking protein Gene

Homo sapiens

Also known as IMD85

Gene ID: 10043 | Gene type: protein coding

About TOM1

Cytogenetic location: 22q12.3 Genomic coordinates (GRCh38): 22:35,299,275-35,347,973 (from NCBI)

This gene has 18 transcripts (splice variants), 221 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 24.4), esophagus (RPKM 24.1) and 25 other tissues.

Summary

This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

TOM1 Products(4)

mRNA	Protein	Name
NM_001135729.2	NP_001129201.1	target of Myb1 membrane trafficking protein isoform 3
NM_001135730.2	NP_001129202.1	target of Myb1 membrane trafficking protein isoform 4
NM_001135732.2	NP_001129204.1	target of Myb1 membrane trafficking protein isoform 2
NM_005488.3	NP_005479.1	target of Myb1 membrane trafficking protein isoform 1

TOM1 Protein Structure

VHS

GAT

0
100
200
300
400
492 a.a.

Protein Preferred Names

Protein Names

target of Myb1 membrane trafficking protein

target of Myb protein 1

target of myb 1

Related Diseases

Diseases

Alias

Immunodeficiency 85 And Autoimmunity

IMD85

Immunodeficiency 85

Immunodeficiency 31c

IMD31C	Candidiasis, Familial, 7
Candf7	Candidiasis, Familial Chronic Mucocutaneous, Autosomal Dominant
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome	Autoimmune Enteropathy And Endocrinopathy - Susceptibility To Chronic Infections Syndrome
Immunodeficiency 31c, Chronic Mucocutaneous Candidiasis, Autosomal Dominant	Autosomal Dominant Chronic Mucocutaneous Familial Candidiasis
Autosomal Dominant Immunodeficiency 31c	Familial Candidiasis 7
Chronic Mucocutaneous Candidiasis 7	Immunodeficiency 31c, Autosomal Dominant
Immunodeficiency, Type 31c, Autosomal Dominant

Autoimmune Enteropathy

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

X-Linked Nephrolithiasis Type I

Nephrolithiasis 1	Nephrolithiasis X-Linked Recessive Type 1
Nphl1	X-Linked Nephrolithiasis With Renal Failure
X-Linked Recessive Urolithiasis Type 1	Xrn

Congenital Muscular Dystrophy-Dystroglycanopathy Type A6

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A6	Mddga6
Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Large-Related	Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A6

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14876	TOM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14877	TOM1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14878	TOM1L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TOM1	VGNC	VGNC:66441
Macaca mulatta	TOM1	VGNC	VGNC:78615
Mus musculus	TOM1	MGD	MGI:1338026
Rattus norvegicus	TOM1	RGD	RGD:1308024
Canis familiaris	TOM1	VGNC	VGNC:47707
Bos taurus	TOM1	VGNC	VGNC:36217

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