Nfatc1 - nuclear factor of activated T-cells 1 Gene

Rattus norvegicus

Gene ID: 100361818 | Gene type: protein coding

About Nfatc1

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription coactivator binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Apr 2022]

Nfatc1 Products(1)

mRNA	Protein	Name
NM_001244933.1	NP_001231862.1	nuclear factor of activated T-cells, cytoplasmic 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	14979875	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12557015	RGD
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	22566696	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	23110133	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	23110133	RGD
involved in mononuclear cell differentiation	IEP IEP: Inferred from expression pattern	23110133	RGD
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	18667424	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	14979875	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	30907990	RGD
involved in skeletal muscle adaptation	IEP IEP: Inferred from expression pattern	24284598	RGD
involved in wound healing	IMP IMP: Inferred from mutant phenotype	18675800	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	14979875	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	18675800	RGD
located in sarcoplasm	IDA IDA: Inferred from direct assay	30907990	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear factor of activated T-cells, cytoplasmic 1

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113756A	Latanoprost acid	Inhibitor	99.62%	Unkown

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0656	Usnic acid		98.90%	Unkown
HY-N2119	Sciadopitysin	Inhibitor	≥99.0%	Unkown
HY-147369	NFATc1-IN-1	Inhibitor	99.97%	Unkown
HY-N0231	Bavachalcone		99.90%	Unkown
HY-15001G	Stemregenin 1 (GMP)	Antagonist	/	Unkown
HY-N2157	Pteryxin	Inhibitor	99.96%	Unkown
HY-123503	Salicortin	Inhibitor	/	Unkown
HY-124958	NDMC101	Inhibitor	99.91%	Unkown
HY-149852	Anti-osteoporosis agent-3		/	Unkown
HY-162280	PROTAC BTK Degrader-9		/	Unkown
HY-175232	GL64		/	Unkown
HY-N12604	Penicisteck acid F	Inhibitor	/	Unkown
HY-N2528	Usnic acid sodium	Inhibitor	/	Unkown
HY-N3071	Picrasidine I		/	Unkown
HY-P4684	Osteostatin		/	Unkown
HY-RS09238	NFATC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W641445	ELP-004	Inhibitor	/	Unkown
HY-RS18427	Nfatc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24908	Nfatc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nfatc1	NCBI	NCBI:4772

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