2. Gene
  3. ROS1 - ROS proto-oncogene 1, receptor tyrosine kinase Gene

ROS1 - ROS proto-oncogene 1, receptor tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Bos taurus
Gene ID: 100336768 | Gene type: protein coding

About ROS1

Primary_assembly 9: 33,364,608-33,480,511 forward strand.ARS-UCD1.2:CM008176.2

This gene has 6 transcripts (splice variants), 125 orthologues and 56 paralogues.

ROS1 Products(1)

mRNA Protein Name
XM_024996960.1 XP_024852728.1 proto-oncogene tyrosine-protein kinase ROS

ROS1 Protein Structure

FN3

FN3: smart00060 (110 - 177)

FN3

FN3: cd00063 (210 - 289)

FN3

FN3: cd00063 (566 - 662)

FN3

FN3: cd00063 (955 - 1022)

FN3

FN3: cd00063 (1035 - 1141)

FN3

FN3: cd00063 (1650 - 1741)

FN3

FN3: cd00063 (1746 - 1835)

PTKc_c-ros

PTKc_c-ros: cd05044 (1942 - 2209)

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  • 2000
  • 2341 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase ROS

c-ros oncogene 1 , receptor tyrosine kinase

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50878 Crizotinib 99.97% Yes
HY-12215 Lorlatinib 99.92% Yes
HY-12678 Entrectinib 99.87% Yes
HY-W015913 Sodium 2-oxopropanoate Inhibitor 99.86% Yes
HY-103022 Repotrectinib Inhibitor 99.90% Unkown
HY-50878A Crizotinib hydrochloride 99.86% Unkown
HY-50878B Crizotinib acetate Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-145574 Iruplinalkib Inhibitor 99.29% Phase 3
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-131003 Taletrectinib Inhibitor 99.78% Phase 2
HY-152292 Zidesamtinib Inhibitor 99.55% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
HY-131003A Taletrectinib free base Inhibitor / Phase 2
Pre-clinical Phase
Bioactive Molecules (44)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0578 Apigenin 7-glucoside 98.97% Unkown
HY-W015913S Sodium 2-oxopropanoate-13C3 Inhibitor 99.7% Unkown
HY-155163 APG-2449 Inhibitor 98.93% Unkown
HY-12678S1 Entrectinib-d8 99.82% Unkown
HY-50878S Crizotinib-d5 ≥99.0% Unkown
HY-147413 Unecritinib Inhibitor 98.83% Unkown
HY-B1106 Tetrahydroxyquinone ≥98.0% Unkown
HY-112801 F-1 Inhibitor 98.03% Unkown
HY-B1106A Tetrahydroxyquinone monohydrate Activator ≥97.0% Unkown
HY-122311 Orniplabin Inhibitor / Unkown
HY-12678S Entrectinib-d4 Inhibitor / Unkown
HY-N1306 Sideroxylin / Unkown
HY-N7798 Pennogenin 98.69% Unkown
HY-W015913R Sodium 2-oxopropanoate (standard) Inhibitor / Unkown
HY-161358 FAK-IN-20 / Unkown
HY-111416 WY-135 Inhibitor / Unkown
HY-135509 Lorlatinib acetate / Unkown
HY-159147 SIA​​IS039 / Unkown
HY-117420 CM764 Activator / Unkown
HY-120387 SMU-B Inhibitor / Unkown
HY-123454 SKF1 / Unkown
HY-130794 ALK/ROS1-IN-1 Inhibitor / Unkown
HY-144697 p38 MAPK-IN-3 / Unkown
HY-147795 Nampt-IN-8 / Unkown
HY-150974 ROS1-IN-1 Inhibitor / Unkown
HY-153743 Protein kinase inhibitor 4 Inhibitor / Unkown
HY-155178 Antiproliferative agent-34 Inhibitor / Unkown
HY-156360 Xanthine oxidase-IN-12 Inhibitor / Unkown
HY-157391 ALK/ROS1-IN-3 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-158016 Antiproliferative agent-49 / Unkown
HY-161966 VEGFR-2-IN-52 / Unkown
HY-161975 ROS1-IN-2 Inhibitor / Unkown
HY-162311 Anticancer agent 194 / Unkown
HY-162488 Laccase-IN-3 Inhibitor / Unkown
HY-163862 PPARα agonist 3 / Unkown
HY-50878AS Crizotinib-d9 hydrochloride / Unkown
HY-N11887 Linocinnamarin Inhibitor / Unkown
HY-N2693 6,8-Diprenylorobol / Unkown
HY-RS12135 ROS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12136 Ros1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS12137 ROS1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-160172 ALK/ROS1-IN-4 Inhibitor / Unkown
HY-160172A ALK/ROS1-IN-4 hydrate Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ROS1 NCBI NCBI:6098