KLLN - killin, p53 regulated DNA replication inhibitor Gene

Homo sapiens

Also known as CWS4; KILLIN

Gene ID: 100144748 | Gene type: protein coding

About KLLN

Cytogenetic location: 10q23.31 Genomic coordinates (GRCh38): 10:87,859,158-87,863,533 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 13 orthologues and is associated with 3 phenotypes.

Summary

The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to Apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]

KLLN Products(1)

mRNA	Protein	Name
NM_001126049.2	NP_001119521.1	killin

Protein Preferred Names

Protein Names

killin

Related Diseases

Diseases

Alias

Cowden Syndrome 4

CWS4	Cowden Syndrome, Type 4

Cowden Syndrome

Cowden Disease	Multiple Hamartoma Syndrome
Cowden'S Disease	Lhermitte-Duclos Disease
Cd	Cs
Mham	Dysplastic Gangliocytoma Of Cerebellum
Cowden'S Syndrome	Hamartoma Syndrome, Multiple

Hereditary Breast Cancer

Familial Breast Cancer	Familial Breast Carcinoma
Hereditary Breast Carcinoma

Cowden Syndrome 1

Bannayan-Riley-Ruvalcaba Syndrome	Pten Hamartoma Tumor Syndrome
Lhermitte-Duclos Disease	Bannayan-Zonana Syndrome
Phts	Riley-Smith Syndrome
Bzs	Ruvalcaba-Myhre-Smith Syndrome
Multiple Hamartoma Syndrome	Rmss
Brrs	Dysplastic Gangliocytoma Of The Cerebellum
CWS1	Cs
Cd	Mham
Pten Hamartoma Tumor Syndrome With Granular Cell Tumor	Macrocephaly Multiple Lipomas And Hemangiomata
Bannayan-Ruvalcaba-Riley Syndrome	Myhre-Riley-Smith Syndrome
LDD	Cerebelloparenchymal Disorder Vi
Hamartoma Syndrome, Multiple	Bbrs
Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata	Macrocephaly, Multiple Lipomas, And Hemangiomata
Macrocephaly Pseudopapilledema And Multiple Hemangiomas	Ruvalcaba -Myhre-Smith Syndrome
Ruvalcaba-Myhre Syndrome	Cowden Disease
Macrocephaly Pseudopapilledema And Multiple Hemangiomata	Cerebellar Granule Cell Hypertrophy And Megalencephaly
Cpd6	Pten Hamartoma Tumor Syndromes
Cowden Syndrome, Type 1

Infiltrating Angiolipoma

Angiolipoma, Infiltrating

Gangliocytoma

Ganglioneuroma

Gangliocytoma Of Central Nervous System

Liver Inflammatory Pseudotumor

Inflammatory Pseudotumor Of The Liver

Liver Inflammatory Myofibroblastic Tumor

Multinodular Goiter

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158820	Cosdosiran		/	Unkown
HY-158820A	Cosdosiran sodium		/	Unkown
HY-E70364	IgdE protease		/	Unkown
HY-RS07389	KLLN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KLLN	RGD	RGD:7720631

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