1. Gene
  2. TEN1 - TEN1 subunit of CST complex Gene

TEN1 - TEN1 subunit of CST complex Gene

Homo sapiens

Also known as C17orf106

Gene ID: 100134934 | Gene type: protein coding

About TEN1

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,979,240-76,000,586 (from NCBI)

This gene has 5 transcripts (splice variants) and 182 orthologues. Ubiquitous expression in small intestine (RPKM 13.6), fat (RPKM 12.7) and 25 other tissues.

Summary

C17ORF106, or TEN1, appears to function in a telomere-associated complex with STN1 (OBFC1; MIM 613128) and CTC1 (C17ORF68; MIM 613129) (Miyake et al., 2009 [PubMed 19854130]).[supplied by OMIM, Nov 2009]

TEN1 Products(1)

mRNA Protein Name
NM_001113324.3 NP_001106795.2 CST complex subunit TEN1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19854130 GOA
enables telomeric DNA binding IDA
IDA: Inferred from direct assay
19854130 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of telomere maintenance via telomerase IDA
IDA: Inferred from direct assay
22763445 GOA
Cellular Component GO Annotation Evidence Reference Source
part of CST complex IDA
IDA: Inferred from direct assay
19854130 GOA
located in chromosome, telomeric region IDA
IDA: Inferred from direct assay
19854130 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19854130 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEN1 Protein Structure

Ten1_2

Ten1_2: Telomere-capping, CST complex subunit (4 - 119)

  • 0
  • 100
  • 123 a.a.
Protein Preferred Names Protein Names

CST complex subunit TEN1

TEN1 telomerase capping complex subunit homolog

Related Diseases

Diseases Alias
Dyskeratosis Congenita, Autosomal Recessive 6

DKCB6

Autosomal Recessive Dyskeratosis Congenita 6

Dyskeratosis Congenita, Autosomal Recessive, 6

Dyskeratosis Congenita, Autosomal Recessive, Type 6

Dyskeratosis Congenita, Autosomal Recessive 1

DKCB1

Autosomal Recessive Dyskeratosis Congenita 1

Dyskeratosis Congenita, Autosomal Recessive, 1

Dyskeratosis Congenita, Autosomal Recessive, Type 1

Dyskeratosis Congenita, Autosomal Recessive 3

DKCB3

Autosomal Recessive Dyskeratosis Congenita 3

Dyskeratosis Congenita, Autosomal Recessive, 3

Dyskeratosis Congenita, Autosomal Recessive, Type 3

Immunodeficiency 26

Severe Combined Immunodeficiency Due To Dna-Pkcs Deficiency

Scid Due To Dna-Pkcs Deficiency

Imd26

Immunodeficiency 26, With Or Without Neurologic Abnormalities

Retinal Telangiectasia
Revesz Syndrome

Exudative Retinopathy With Bone Marrow Failure

DKCA5

Dyskeratosis Congenita, Autosomal Dominant 5

Dyskeratosis Congenita With Bilateral Exudative Retinopathy

Retinopathy-Anemia-Central Nervous System Anomalies Syndrome

Revesz-Debuse Syndrome

Dyskeratosis Congenita, Autosomal Dominant, 5

Revesz Debuse Syndrome

Glioblastoma Mesenchymal Subtype
Coats Disease

Exudative Retinopathy

Retinal Telangiectasis

Coats' Disease

Leber Miliary Aneurysm

Coats' Syndrome

Congenital Retinal Telangiectasia

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome

Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

Melanoma, Malignant

CMM1

Melanoma, Cutaneous Malignant

Cmm

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TEN1 RGD RGD:1311078
Bos taurus TEN1 VGNC VGNC:54498
Canis familiaris TEN1 VGNC VGNC:54372
Mus musculus TEN1 MGD MGI:1916785