ZBTB33 - zinc finger and BTB domain containing 33 Gene

Homo sapiens

Also known as ZNF348; ZNF-kaiso

Gene ID: 10009 | Gene type: protein coding

About ZBTB33

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:120,250,812-120,258,398 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 28 paralogues. Ubiquitous expression in skin (RPKM 10.2), bone marrow (RPKM 8.2) and 25 other tissues.

Summary

This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]

ZBTB33 Products(2)

mRNA	Protein	Name
NM_001184742.2	NP_001171671.1	transcriptional regulator Kaiso
NM_006777.4	NP_006768.1	transcriptional regulator Kaiso

ZBTB33 Protein Structure

BTB

zf-H2C2_2

0
200
400
600
672 a.a.

Protein Preferred Names

Protein Names

transcriptional regulator Kaiso

WUGSC:H_DJ525N14.1

Related Diseases

Diseases

Alias

Rett Syndrome

Atypical Rett Syndrome	RTT
Rett Disorder	Rts
Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use	Rett Syndrome, Preserved Speech Variant
Rett Syndrome, Atypical	Rett'S Disorder
Rett Syndrome Variant	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Cerebroatrophic Hyperammonemia	Rett Like Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Cri-Du-Chat Syndrome

5p Deletion Syndrome	5p Partial Monosomy Syndrome
Monosomy 5p	Cat Cry Syndrome
Chromosome 5p Deletion Syndrome	Cri Du Chat Syndrome
5p- Syndrome	5p Minus Syndrome
Chromosome 5p- Syndrome	Chromosome 5 Short Arm Deletion Syndrome
Chromosome 5p Deletion	Deletion 5p
Cri Du Chat	5p Partial Deletion Syndrome
Partial Deletion Of Short Arm Of Chromosome 5 Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15972	ZBTB33 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZBTB33	MGD	MGI:1927290
Canis familiaris	ZBTB33	VGNC	VGNC:48531
Rattus norvegicus	ZBTB33	RGD	RGD:1566309
Felis catus	ZBTB33	VGNC	VGNC:67165
Macaca mulatta	ZBTB33	VGNC	VGNC:79043
Bos taurus	ZBTB33	VGNC	VGNC:37073

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