2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. GDC-0310

GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7.

For research use only. We do not sell to patients.

GDC-0310 Chemical Structure

GDC-0310 Chemical Structure

CAS No. : 1788063-52-4

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Customer Review

Based on 1 publication(s) in Google Scholar

GDC-0310 Related Antibodies

Top Publications Citing Use of Products

View All Sodium Channel Isoform Specific Products:

View All Isoforms
Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8 Nav1.9

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GDC-0310 is a selective acyl-sulfonamide Nav1.7 inhibitor, with an IC50 of 0.6 nM for hNav1.7[1].

IC50 & Target[1]

hNav1.4

3.4 nM (IC50)

hNav1.2

38 nM (IC50)

hNav1.6

198 nM (IC50)

hNav1.1

202 nM (IC50)

hNav1.5

551 nM (IC50)

Nav1.7

0.6 nM (IC50)

In Vitro

GDC-0310 exhibits an EC50 of 1.1 μM in vivo and a Ki of 1.8 nM for Nav1.7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GDC-0310 Related Antibodies
In Vivo

GDC-0310 shows substantially improved Nav selectivity and ADME properties[1].
GDC-0310 exhibits t1/2 values of 5 h, 46 h and 4.4 h in rat (5 mg/kg, iv), dog (1 mg/kg, iv) and cynomolgus monkeys (2 mg/kg, iv), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

543.48

Formula

C25H29Cl2FN2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NS(=O)(C)=O)C1=CC(C2CC2)=C(OCC3CCN([C@H](C4=CC(Cl)=CC(Cl)=C4)C)CC3)C=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 4 mg/mL (7.36 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8400 mL 9.2000 mL 18.3999 mL
5 mM 0.3680 mL 1.8400 mL 3.6800 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8400 mL 9.2000 mL 18.3999 mL 45.9999 mL
5 mM 0.3680 mL 1.8400 mL 3.6800 mL 9.2000 mL
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GDC-0310 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GDC-03101788063-52-4GDC0310GDC 0310Sodium ChannelNa channelsNa+ channelspainNav1.7Inhibitorinhibitorinhibit

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