FMAU (Synonyms: D-FMAU)

Cat. No.: HY-114247 Purity: 98.66%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

FMAU is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.

For research use only. We do not sell to patients.

FMAU Chemical Structure

CAS No. : 69256-17-3

Size	Stock	Quantity
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote	Estimated Time of Arrival: December 31
5 g	Get quote	Estimated Time of Arrival: December 31
10 g	Get quote
50 g	Get quote

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Description

FMAU is a thymidine analogue. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	> 1 mM Compound: 14	Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay Inhibition of human promyelocytic leukemic cell (HL-60) by XXT-microculture tetrazolium assay	[PMID: 2033590]
Vero	ED₅₀	0.018 μM Compound: 1a	Compound was tested for antiviral activity against Herpes simplex virus-1 (Strain F) in vero cells by plaque reduction assay. Compound was tested for antiviral activity against Herpes simplex virus-1 (Strain F) in vero cells by plaque reduction assay.	[PMID: 3001306]
Vero	ED₅₀	0.023 μM Compound: 1a	Compound was tested for antiviral activity against Herpes simplex virus-2 (Strain G) in vero cells by plaque reduction assay. Compound was tested for antiviral activity against Herpes simplex virus-2 (Strain G) in vero cells by plaque reduction assay.	[PMID: 3001306]

Molecular Weight

260.22

Formula

C₁₀H₁₃FN₂O₅

CAS No.

69256-17-3

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@H](F)[C@H](N(C(N2)=O)C=C(C)C2=O)O[C@@H]1CO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (480.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8429 mL	19.2145 mL	38.4290 mL
5 mM	0.7686 mL	3.8429 mL	7.6858 mL
10 mM	0.3843 mL	1.9215 mL	3.8429 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.66%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (252 KB) HNMR (267 KB) LCMS (104 KB)

Handling Instructions (2659 KB)

References

[1]. Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16(9):7980-93. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8429 mL	19.2145 mL	38.4290 mL	96.0726 mL
	5 mM	0.7686 mL	3.8429 mL	7.6858 mL	19.2145 mL
	10 mM	0.3843 mL	1.9215 mL	3.8429 mL	9.6073 mL
	15 mM	0.2562 mL	1.2810 mL	2.5619 mL	6.4048 mL
	20 mM	0.1921 mL	0.9607 mL	1.9215 mL	4.8036 mL
	25 mM	0.1537 mL	0.7686 mL	1.5372 mL	3.8429 mL
	30 mM	0.1281 mL	0.6405 mL	1.2810 mL	3.2024 mL
	40 mM	0.0961 mL	0.4804 mL	0.9607 mL	2.4018 mL
	50 mM	0.0769 mL	0.3843 mL	0.7686 mL	1.9215 mL
	60 mM	0.0640 mL	0.3202 mL	0.6405 mL	1.6012 mL
	80 mM	0.0480 mL	0.2402 mL	0.4804 mL	1.2009 mL
	100 mM	0.0384 mL	0.1921 mL	0.3843 mL	0.9607 mL

FMAU Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FMAU69256-17-3D-FMAUNucleoside Antimetabolite/Analoglabelingtrack DNA synthesisInhibitorinhibitorinhibit

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FMAU (Synonyms: D-FMAU)

FMAU Related Antibodies

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